MMP-mediated cleavage of beta-dystroglycan in myelin sheath is involved in autoimmune neuritis

Biochemical and Biophysical Research Communications
Xiu Li ZhaoDi Zhong

Abstract

Alpha-/beta-dystroglycans (DG) located at the outmost layer of myelin sheath play a critical role in its formation and stability in the peripheral nerve system. The demyelination of nerve fibers is present in autoimmune neuritis, however, it is not known about the molecular mechanisms underlying this pathological process. In an animal model of experimental autoimmune neuritis, we observed that beta-DG cleavage was associated with the demyelination of peripheral nerves. The neuritis and beta-DG cleavage were accompanied by matrix metalloproteinase (MMP)-2/-9 over-expressions and attenuated by captopril, a MMP inhibitor. The blockade of MMPs also improves clinical signs. Our results reveal a crucial role of MMP-mediated beta-DG cleavage in autoimmune neuritis, such as Guillain-Barre' syndrome, and bring insights into therapeutic strategies for autoimmune diseases.

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Citations

Aug 26, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Felipe A CourtM Laura Feltri
Jan 6, 2012·Neurochemical Research·Yongwei QinChun Cheng
Aug 7, 2017·Journal of Cellular and Molecular Medicine·Malgorzata Ziemka-NaleczJoanna Sypecka

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