MMP-Responsive 'Smart' Drug Delivery and Tumor Targeting

Trends in Pharmacological Sciences
Qing YaoLin Zhu

Abstract

Matrix metalloproteinases (MMPs) are major extracellular enzymes involved in cancer initiation, progression, and metastasis. MMPs are widely used as cancer biomarkers and therapeutic targets. Recently, MMPs have been investigated as robust tumor microenvironmental stimuli for 'smart' MMP-responsive drug delivery and tumor targeting and have shown great potential in cancer diagnosis and therapy. In this article, we review the newly emerging MMP-responsive strategies and major MMP-responsive nanomaterials and nanocarriers used for tumor-targeted delivery of drugs and imaging agents at the tissue, cellular, and intracellular levels. We also discuss the challenges and critical considerations in their development and clinical translation.

Citations

Sep 1, 2018·Expert Opinion on Drug Delivery·Longfa KouRuijie Chen
Jan 29, 2019·Current Topics in Medicinal Chemistry·Yanan LiFeifei An
Aug 17, 2019·Chemistry : a European Journal·Alberto Dal CorsoCesare Gennari
Dec 19, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Qing YaoYing-Zheng Zhao
Jan 29, 2020·BioImpacts : BI·Marziyeh FathiJaleh Barar
May 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheng Lian, Tianjiao Ji
Sep 16, 2019·Journal of Translational Medicine·Shuaishuai XuLiang Liu
Sep 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Khan MuhammadYakai Feng
Sep 3, 2019·Frontiers in Bioengineering and Biotechnology·Catarina Roma-RodriguesPedro V Baptista
Feb 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Si ChenXian-Zheng Zhang
Oct 3, 2018·International Journal of Molecular Sciences·Ying WangZhe Yang
Mar 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoqin ChiJinhao Gao
Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Priscilla S BriquezJeffrey A Hubbell
May 30, 2020·Cells·Maryam Raeeszadeh-SarmazdehBrianne G Hritz
Feb 20, 2019·International Journal of Molecular Sciences·Catarina Roma-RodriguesAlexandra R Fernandes
Jul 8, 2020·International Journal of Molecular Sciences·Giovanni Barillari
Oct 20, 2020·Advanced Healthcare Materials·Hyeongmok ParkWon Jong Kim
Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Dec 31, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Qingguo ZhaoFei Liu
Jan 28, 2021·Drug Delivery·Jingou LiangLei Cheng
Dec 22, 2020·Bioorganic & Medicinal Chemistry Letters·Dan LouShihui Bao
Feb 9, 2021·ACS Nano·Alexander B Cook, Paolo Decuzzi
Feb 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Bo TangHaojie Huang
Oct 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara Maslanka FigueroaAchim Goepferich
Nov 30, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Muhammad Muzamil KhanVladimir P Torchilin
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Longfa KouRuijie Chen
Apr 21, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Qing YaoLin Zhu

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