MMPI as a measure of subthreshold and residual psychopathology among the offspring of lithium responsive and non-responsive bipolar parents

Bipolar Disorders
Natasha DemidenkoAnne Duffy

Abstract

In bipolar adults, the Minnesota Multiphasic Personality Inventory (MMPI) can detect residual symptoms and confirm completeness of remission, thus helping to predict response to lithium prophylaxis. In the high-risk and early onset bipolar populations, the association of the MMPI with clinical course and treatment response has not yet been studied. The present study compares MMPI profiles completed by the well or remitted offspring of two groups of bipolar parents divided on the basis of parental response to long-term lithium. As part of an ongoing prospective longitudinal high-risk study, offspring of bipolar parents determined to either respond or not respond to long-term lithium monotherapy completed the MMPI. At the time of MMPI completion, offspring were determined to be either well (unaffected) or clinically remitted (affected but euthymic) based on repeated prospective KSADS-PL format interviews conducted by a research psychiatrist and reviewed on a blind consensus basis. While there was no difference in the MMPI scores between subgroups of unaffected offspring, there was a significant difference in profiles between remitted offspring. Specifically, affected offspring of lithium non-responders showed significantly higher...Continue Reading

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Citations

May 16, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ewa FerensztajnJanusz K Rybakowski
Apr 29, 2015·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Moon-Doo KimWon-Myong Bahk
Oct 8, 2009·Acta Psychiatrica Scandinavica·P GrofT Hajek
Aug 11, 2007·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Anne Duffy
Aug 19, 2007·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Anne DuffyPaul Grof
Aug 21, 2010·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Anne Duffy

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Bipolar Disorder

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