PMID: 11906808Mar 22, 2002Paper

MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology

Progress in Retinal and Eye Research
J M Sivak, M E Fini

Abstract

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that function to maintain and remodel tissue architecture. Their substrates represent an astounding variety of extracellular matrix components, secreted cytokines and cell surface molecules, and they have been implicated in a wide range of processes and diseases. To date MMPs have been found in virtually every tissue of the eye under conditions of health and disease. Although their functions in vivo remain poorly understood, it is clear they impact on essentially every aspect of eye physiology. This chapter reviews the expanding literature on MMPs in the eye and attempts to place it in the context of basic MMP biology. A general overview of MMP functions is presented first, and then the discussion moves to examples of possible MMP roles in two eye structures. For the cornea, we present recent work on the roles of MMPs during various aspects of wound healing. For the retina, we describe the activities of MMPs in specific disease states from which common principles may emerge.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B Johnson-Muller, J Gross
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G I GoldbergC S He
Apr 1, 1967·Developmental Biology·H C Grillo, J Gross
Oct 1, 1968·Archives of Ophthalmology·H H SlanskyM Itoi
Aug 28, 1995·Brain Research. Developmental Brain Research·R Cañete SolerR J Muschel
Sep 1, 1995·The Journal of Investigative Dermatology·T V KarelinaA Z Eisen
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·J A West-MaysM E Fini
Sep 1, 1994·Current Eye Research·D BrownM C Kenney
Aug 1, 1993·Journal of Cellular Physiology·H W SchnaperD L French
Sep 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R Cañete-SolerR J Muschel
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J M ShipleyS D Shapiro
May 17, 1996·The Journal of Biological Chemistry·G PreeceA Ager
Jan 1, 1996·The British Journal of Ophthalmology·J Evans, R Wormald
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·E LeviI Vlodavsky
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C L WilsonL M Matrisian
Mar 24, 1998·Reviews of Reproduction·E W McIntush, M F Smith
May 29, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J FitchT F Linsenmayer

❮ Previous
Next ❯

Citations

Dec 10, 2008·Archives of Ophthalmology·Beeran MeghparaDeepak P Edward
Aug 12, 2009·Archives of Ophthalmology·Beeran MeghparaDeepak P Edward
Aug 31, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chrysanthos SymeonidisStavros A Dimitrakos
Oct 10, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Seppo RönkköHannu Uusitalo
Dec 21, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chrysanthos SymeonidisStavros A Dimitrakos
Jul 3, 2013·Journal of Neuro-oncology·Wen-Chiuan TsaiDueng-Yuan Hueng
Jul 16, 2008·Stem Cell Reviews·Genevieve A Secker, Julie T Daniels
Nov 12, 2003·Experimental Eye Research·Julie T DanielsUlpu Saarialho-Kere
Nov 9, 2004·Survey of Ophthalmology·Suphi TaneriDimitri T Azar
Feb 1, 2003·Archives of Biochemistry and Biophysics·Irina G SurguchevaAndrei P Surguchov
Dec 17, 2010·Gene Therapy·S D GaliacyF Malecaze
Mar 15, 2013·Nature Reviews. Cancer·S Patricia Becerra, Vicente Notario
Sep 11, 2004·Eye·S S Zaher, K Ramaesh
Jun 10, 2005·Biology of Reproduction·Tu'uhevaha J Kaitu'uLois A Salamonsen
Jun 10, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rupak MukherjeeFrancis G Spinale
Dec 29, 2012·Eye & Contact Lens·Meng C Lin, Thao N Yeh
Apr 9, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Maria MarkoulliBrien Holden
Mar 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J A EldredI M Wormstone
Nov 30, 2012·Journal of Biomedicine & Biotechnology·Irena TsuiSteven D Schwartz
May 26, 2005·Investigative Ophthalmology & Visual Science·Raghuveer S MaliShravan K Chintala
May 26, 2006·Investigative Ophthalmology & Visual Science·Wei LiScheffer C G Tseng
Sep 20, 2005·Genome Biology·Jennifer J DiehnPatrick O Brown
Nov 3, 2012·PloS One·Andrea Rachelle C SantosMichaela Livia Bajenaru
Mar 28, 2013·Journal of Ophthalmology·Shivalingappa K Swamynathan
Nov 13, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sirpa LoukovaaraJorma Keski-Oja
Jan 15, 2014·Progress in Retinal and Eye Research·Jenny R Lenkowski, Pamela A Raymond
Jul 10, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tohru SakimotoAkiko Ishimori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.