MMR vaccination and autism : what is the evidence for a causal association?

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Kreesten M Madsen, Mogens Vestergaard

Abstract

It has been suggested that vaccination with the measles-mumps-rubella (MMR) vaccine causes autism. The wide-scale use of the MMR vaccine has been reported to coincide with the apparent increase in the incidence of autism. Case reports have described children who developed signs of both developmental regression and gastrointestinal symptoms shortly after MMR vaccination.A review of the literature revealed no convincing scientific evidence to support a causal relationship between the use of MMR vaccines and autism. No primate models exist to support the hypothesis. The biological plausibility remains questionable and there is a sound body of epidemiological evidence to refute the hypothesis. The hypothesis has been subjected to critical evaluation in many different ways, using techniques from molecular biology to population-based epidemiology, and with a vast number of independent researchers involved, none of which has been able to corroborate the hypothesis.

References

Mar 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·C GillbergH Schaumann
Mar 1, 1991·The Pediatric Infectious Disease Journal·A Sugiura, A Yamada
Jun 22, 1989·The New England Journal of Medicine·D E GriffinA Vaisberg
Mar 15, 1986·British Medical Journal·S SheppardH Holzel
May 8, 1967·JAMA : the Journal of the American Medical Association·S A PlotkinT Furukawa
Jan 19, 1984·The New England Journal of Medicine·R T JohnsonA Vaisberg
Dec 1, 1995·American Journal of Public Health·S Rosenthal, R Chen
May 31, 1995·Annals of the New York Academy of Sciences·P D Parkman
Apr 1, 1996·Journal of Autism and Developmental Disorders·J Bachevalier
Oct 3, 1998·Clinical Immunology and Immunopathology·V K SinghV C Yang
Sep 18, 1999·Lancet·A J Wakefield
Mar 4, 2000·Cellular and Molecular Neurobiology·M B Segal
Sep 28, 2000·The American Journal of Gastroenterology·A J WakefieldJ A Walker-Smith
Mar 20, 2001·JAMA : the Journal of the American Medical Association·L DalesN J Smith
Jun 8, 2001·Vaccine·C P FarringtonB Taylor
Sep 13, 2001·Mental Retardation and Developmental Disabilities Research Reviews·M Hornig, W I Lipkin
Oct 3, 2001·Pediatrics·E Fombonne, S Chakrabarti
Apr 26, 2002·The Journal of Infection·E Miller
Nov 5, 2002·Pediatrics·Annamari MäkeläHeikki Peltola
Nov 8, 2002·The New England Journal of Medicine·Kreesten Meldgaard MadsenMads Melbye
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Marshalyn Yeargin-AllsoppCatherine Murphy
Apr 23, 2003·Archives of Neurology·Frank DeStefanoUNKNOWN Vaccine Safety Datalink Research Group, National Immunization Program, Centers for Disease Control and Prevention
Jun 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·J F ENDERS, T C PEEBLES
Oct 24, 1959·Journal of the American Medical Association·F A GIBBSH W SPIES
Mar 1, 1962·American Journal of Diseases of Children·F C ROBBINS

❮ Previous
Next ❯

Citations

Sep 27, 2007·Reviews on Environmental Health·Scott C Bello
Dec 18, 2013·International Journal of Environmental Research and Public Health·Woody R McGinnisStephen M Edelson
Nov 7, 2006·Brain & Development·Dimitrios I ZafeiriouEuthymia Vargiami
May 13, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·John IskanderUNKNOWN VAERS Team
Jan 22, 2009·Acta Neurologica Scandinavica·C AhlgrenO Andersen
Aug 14, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Christopher L CummingsWei Yi Kong
Dec 30, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Raja BenkiraneShanti N Pal
Sep 6, 2013·British Journal of Nursing : BJN·Marie C Hill, Carol L Cox

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jeffrey S Gerber, Paul A Offit
Journal of Child Psychology and Psychiatry, and Allied Disciplines
Hideo HondaM Rutter
© 2021 Meta ULC. All rights reserved