MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs)

Experimental and Molecular Pathology
Joongho JohA Bennett Jenson

Abstract

Infection by mouse papillomavirus (PV), MmuPV1, of T cell-deficient, B6.Cg-Foxn1(nu)/J nude mice revealed that four, distinct squamous papilloma phenotypes developed simultaneously after infection of experimental mice. Papillomas appeared on the muzzle, vagina, and tail at or about day 42days post-inoculation. The dorsal skin developed papillomas and hair follicle tumors (trichoblastomas) as early as 26days after infection. Passive transfer of hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs) to T cell-deficient strains of mice prevented infection by virions of experimental mice. This study provides further evidence that T cell deficiency is critical for tumor formation by MmuPV1 infection.

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Citations

Sep 5, 2017·Viruses·Jiafen HuNeil D Christensen
Sep 26, 2017·The Journal of General Virology·Nancy M CladelJiafen Hu
Nov 2, 2019·Nature·John D StrickleyShadmehr Demehri
Feb 14, 2020·Journal of Virology·Megan E Spurgeon, Paul F Lambert
Mar 24, 2018·Frontiers in Microbiology·Jordan M MeyersKarl Munger
Sep 25, 2017·Experimental and Molecular Pathology·Joongho JohAlfred B Jenson

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