Mnemonic effects of testosterone and its 5alpha-reduced metabolites in the conditioned fear and inhibitory avoidance tasks

Pharmacology, Biochemistry, and Behavior
Kassandra EdingerCheryl A Frye

Abstract

Experiments were conducted to examine whether performance in hippocampally-mediated learning tasks is influenced by testosterone (T) and/or its 5alpha-reduced metabolites, dihydrotestosterone (DHT) and 3alpha-androstanediol (3alpha-diol). Performance in the conditioned fear and inhibitory avoidance tasks were examined in intact and gonadectomized (GDX), androgen-replaced rats. In Experiment 1, the behavior of intact and GDX rats in the conditioned fear paradigm were compared. GDX rats spent more time freezing, an index of increased learning, in the context, hippocampally-mediated task, but not in the cued, amygdala-mediated task. In Experiment 2, GDX rats were administered T, DHT, 3alpha-diol, estrogen (E2), or vehicle 1 mg/kg sc after training in the conditioned fear paradigm. T-, 3alpha-diol-, or E2-, compared with vehicle-administered rats, spent significantly more time freezing in the contextual, but not the cued, condition. In Experiment 3, intact compared with GDX rats had significantly longer crossover latencies, indicating better performance, in the inhibitory avoidance task. In Experiment 4, T, DHT, 3alpha-diol, or vehicle 1 mg/kg sc was administered to GDX rats immediately following training in the inhibitory avoidanc...Continue Reading

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Citations

Jul 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cheryl A FryeKanako Sumida
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary F Kritzer, Lela M Creutz
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vanessa A SkucasHelen E Scharfman
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Nov 3, 2009·Physiology & Behavior·Jennifer M Barker, Liisa A M Galea
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Madeline E Rhodes, Cheryl A Frye
Aug 15, 2006·Neurobiology of Learning and Memory·Kassandra L Edinger, Cheryl A Frye
Feb 14, 2006·Hormones and Behavior·Tomás A Fregoso-Aguilar, Sergio R Zamudio
Jan 10, 2012·Physiology & Behavior·Carmel M McDermottLaura A Schrader
May 19, 2009·Pharmacology, Biochemistry, and Behavior·Danielle C Llaneza, Cheryl A Frye
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Oct 24, 2021·Frontiers in Neuroendocrinology·Arnaud JeanHélène Hardin-Pouzet

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