Mn(II) and Zn(II) interactions with peptide fragments from Parkinson's disease genes

Dalton Transactions : an International Journal of Inorganic Chemistry
Serenella MediciMaria Antonietta Zoroddu

Abstract

Two peptide sequences from PARK9 Parkinson's disease gene, ProAspGluLysHisGluLeu, (P(1)D(2)E(3)K(4)H(5)E(6)L(7)) (1) and PheCysGlyAspGlyAlaAsnAspCysGly (F(1)C(2)G(3)D(4)G(5)A(6)N(7)D(8)C(9)G(10)) (2) were tested for Mn(II), Zn(II) and Ca(II) binding. The fragments are located from residues 1165 to 1171 and 1184 to 1193 in the PARK9 encoded protein. This protein can protect cells from poisoning of manganese, which is an environmental risk factor for a Parkinson's disease-like syndrome. Mono- and bi-dimensional NMR spectroscopy has been used to understand the details of metal binding sites at different pH values and at different ligand to metal molar ratios. Mn(II) and Zn(II) coordination with peptide (1) involves imidazole N(ε) or N(δ) of His(5) and carboxyl γ-O of Asp(2), Glu(3) and Glu(6) residues. Six donor atoms participate in Mn(II) binding resulting in a distorted octahedral geometry, possibly involving bidentate interaction of carboxyl groups; four donor atoms participate in Zn(II) binding resulting in a tetracoordinate geometry. Mn(II) and Zn(II) coordination involves the two cysteine residues with peptide (2); Mn(II) accepts additional ligand bonds from the carboxyl γ-O of Asp(4) and Asp(8) to complete the coordination ...Continue Reading

References

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Citations

Aug 29, 2013·Biochemistry. Biokhimii︠a︡·S A Shukolyukov
May 3, 2014·TheScientificWorldJournal·Massimiliano Francesco PeanaMaria Antonietta Zoroddu
Oct 11, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Serenella MediciMaria Antonietta Zoroddu
Mar 16, 2017·Archives of Biochemistry and Biophysics·Rodrigo Diaz-EspinozaOctavio Monasterio
Mar 28, 2017·Journal of Inorganic Biochemistry·Massimiliano PeanaMaria Antonietta Zoroddu
Mar 30, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Annaleizle FerrancoHeinz-Bernhard Kraatz
Mar 10, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·J I LachowiczD Choquesillo-Lazarte
Feb 18, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Maurizio RemelliMaria Antonietta Zoroddu
Oct 31, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Maria Antonietta ZorodduHenryk Kozlowski
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Gaobin ZhangWei Huang
Dec 4, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Maurizio RemelliMaria Antonietta Zoroddu
Aug 21, 2020·Learning & Memory·Jack T Rogers, Catherine M Cahill
Sep 18, 2016·Journal of Inorganic Biochemistry·Massimiliano PeanaMaria Antonietta Zoroddu
Jun 11, 2021·Inorganic Chemistry·Koudedja CoulibalyNicolas Delsuc

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