PMID: 8583877Jan 1, 1995Paper

MnPcS4: a new MRI contrast enhancing agent for tumor localisation in mice

Magnetic Resonance Imaging
S K SainiR Singh

Abstract

Manganese-tetrasulfonated phthalocyanine (MnPcS4) has been evaluated as a potential contrast agent in Magnetic resonance imaging (MRI) for tumor localisation in mice. MnPcS4 showed favourable molar relaxivity, much better than Gd-DTPA and comparable to tetrasulfonated manganese complex of porphyrin (TPPS4). Tumors showed selective retention of the metal complex (dye) with the peak value reached at 24 hours following intravenous administration. Dye concentration in tumors remained consistently higher than either kidney or muscle tissue both at 1 and 24 hours and a 10-fold increase in tumor-to-muscle ratio over the control was seen at 24 hr. Normal liver tissue, however, showed higher concentration than tumor at all times during the study. A linear correlation was found between longitudinal relaxation rate (1/T1) and the corresponding concentration of MnPcS4 in various tissues. MR imaging done in animals using 1.5 T superconducting clinical imager showed a mean percent increase in signal intensity of 131.8% (SD +/- 32.86) in the tumor and a 70% increase in tumor-to-muscle ratio over the pretreatment value, at 24 hr. The results suggest that MnPcS4 is a potential tumor-selective contrast agent in MRI.

References

Jan 1, 1987·Magnetic Resonance Imaging·R J FielJ G van Heteren
Jan 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R C LyonP Hambright

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Citations

Jun 15, 2001·ILAR Journal·R S Balaban, V A Hampshire
Jul 19, 2005·Investigative Radiology·Yicheng NiGuy Marchal
Nov 20, 2015·Journal of Inorganic Biochemistry·Sara M A PintoCarlos F G C Geraldes
Aug 28, 2007·Methods : a Companion to Methods in Enzymology·Marc A BrockmannChristoph Groden
Jul 22, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yumiao Zhang, Jonathan F Lovell
May 1, 2010·The Journal of Organic Chemistry·Herwig J BertholdTheo Schotten

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