MntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis

Molecular Microbiology
Ruchi PandeyG M Rodriguez

Abstract

The pathogenic mycobacterium Mycobacterium tuberculosis encodes two members of the DtxR/MntR family of metalloregulators, IdeR and SirR. IdeR represses gene expression in response to ferrous iron, and we here demonstrate that SirR (Rv2788), although also annotated as an iron-dependent repressor, functions instead as a manganese-dependent transcriptional repressor and is therefore renamed MntR. MntR regulates transporters that promote manganese import and genes that respond to metal ion deficiency such as the esx3 system. Repression of manganese import by MntR is essential for survival of M. tuberculosis under conditions of high manganese availability, but mntR is dispensable during infection. In contrast, manganese import by MntH and MntABCD was found to be indispensable for replication of M. tuberculosis in macrophages. These results suggest that manganese is limiting in the host and that interfering with import of this essential metal may be an effective strategy to attenuate M. tuberculosis.

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Citations

Jan 25, 2018·International Journal of Molecular Sciences·Niels A ZondervanMaria Suarez-Diez
Sep 21, 2018·PLoS Pathogens·Cristina Colomer-WinterJosé A Lemos
Nov 28, 2017·Nature Biotechnology·Mohan BabuAndrew Emili
May 8, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ana Laura Granados-TristánKatia Peñuelas-Urquides
Nov 7, 2019·Journal of Bacteriology·Srinand ParuthiyilJohn D Helmann
Aug 10, 2021·Journal of Bacteriology·Eric D PengMichael P Schmitt

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