MO-D-213CD-02: Non-Contrast-Enhanced Magnetic Resonance Angiography Methods for Assessment of Morphology and Flow

Medical Physics
O Wieben

Abstract

Traditional clinical MR Angiography (MRA) provides volumetric datasets to characterize the vessel lumen. These MRA techniques can be generally separated into two categories: • contrast-enhanced MRA, which requires the venous injection of a paramagnetic contrast agent in form of a Gadolinium chelate and • non-contrast-enhanced MRA (NCE MRA), which relies on signal properties of the blood or the motion of the blood to create signal differences between the blood pool and the surrounding tissues. Time-of-Flight (TOF) and Phase- Contrast (PC) imaging have been developed as NCE techniques in the early days of MR imaging. However, widespread clinical adaptation of MRA did not occur until the introduction of CE-MRA in the mid-1990ies with significantly improved robustness. Recent developments have renewed the interest in imaging approaches that do not rely on any external contrast agents. Advances in hardware, especially gradient amplifiers and multi-channel coil technology, have reduced imaging times, improved the signal-to-noise ratio, and reduced artefacts so that NCE MRA is becoming competitive again. These approaches provide viable alternatives in patients that are at risk for nephrogenic systemic fibrosis (NSF) and should not rec...Continue Reading

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