MO-D-217BCD-01: Personalizing Medicine: Adapting to the Individual

Medical Physics
Kristy K BrockP Kupelian

Abstract

Personalizing medicine through patient-specific adaptation is quickly moving from retrospective research to clinical implementation. The commercial availability of clinical tools, including auto-segmentation, deformable registration, and dose accumulation, is enabling these techniques to be utilized more efficiently. Understanding the importance, rationale, and consequences of anatomical and physiological based adaptation is paramount for the safe implementation of these techniques. This includes accounting for radiobiological differences in delivered dose and the impact that this may have on tumor control and normal tissue response. This interactive session will highlight the evidence and rationale for anatomy-based adaptation, including retrospective studies from several anatomical sites indicating the uncertainties between the planned and delivered dose and the benefits achievable through adaptation. Translation of these techniques into the clinic will be discussed. The growing use of functional imaging enables more sophisticated adaptation and personalization of the treatment plan based on an understanding of the individual response of the tumor and normal tissue to radiation. Methods to understand and incorporate this info...Continue Reading

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