MO-F-BRB-06: Gold Nanoparticle Modify Density of Ionizations inside Cells Submitted to Radiation Therapy: Microscopic Track Analysis of Secondary Electrons Using Monte Carlo

Medical Physics
T MarquesP Nicolucci

Abstract

Study density of ionization in cells containing gold nanoparticles (AuNP) submitted to Radiation Therapy. Spherical gold nanoparticles with diameters ranging 0-100nm were considered evenly distributed inside a 20mgr;m cubic cell, maintaining the gold concentration of 0.01%, with constant number of gold atoms inside the cell. Monte Carlo simulations were performed using PENELOPE code considering event-by-event transport of secondary electrons with minimum energy of 1keV. Simulated clinical energy spectrum of 250kV and 6MV x-rays;Co-60 and Ir-192 γ-ray sources obtained at each corresponding build-up depths were considered. Density of ionization inside the cell was evaluated counting delta electrons created either in AuNP or cell, excluding electrons attenuated inside the nanoparticles. The dose enhancement resultant from interaction of electrons with few micrometers range was quantified by the factor μDEF as the ratio of doses inside the cell with and without AuNP. Maps of ionization density were obtained at the central plane of the cell illustrating ionizations around and between AuNP. The density of ionization increases in cell medium as the AuNP diameter enlarges, being higher to larger nanoparticles for all energies studied. ...Continue Reading

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