Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila

Developmental Biology
Li-Lun HoZhi-Chun Lai

Abstract

Growth inhibition mediated by Hippo (Hpo) signaling is essential for tissue growth and organ size control in Drosophila. However, the cellular mechanism by which the core components like Mob as tumor suppressor (Mats) and Warts (Wts) protein kinase are activated is poorly understood. In this work, we found that the endogenous Mats is located at the plasma membrane in developing tissues. Membrane targeting constitutively activates Mats to promote apoptosis and reduce cell proliferation, which leads to reduced tissue growth and organ size. Moreover, the ability of membrane-targeted Mats to inhibit tissue growth required the wts gene activity and Wts kinase activity was increased by the activated Mats in developing tissues. Consistent with the idea that Mats is a key component of the Hpo pathway, Mats is required and sufficient to regulate Yki nuclear localization. These results support a model in which the plasma membrane is an important site of action for Mats tumor suppressor to control tissue growth and organ size.

References

Feb 19, 2002·Genes & Development·François RoyMarc Therrien
Jun 16, 2004·The Journal of Biological Chemistry·Samuel J BichselBrian A Hemmings
Feb 3, 2005·Oncogene·Eunice H Y ChanHerman H W Silljé
Aug 3, 2005·Cancer Research·John BothosThanos D Halazonetis
Sep 2, 2005·Molecular and Cellular Biology·Alexander HergovichBrian A Hemmings
Apr 12, 2006·Nature Reviews. Molecular Cell Biology·Alexander HergovichBrian A Hemmings
May 6, 2006·Biochemical and Biophysical Research Communications·Alexander HergovichBrian A Hemmings
Jul 29, 2006·Annual Review of Genetics·Iswar K Hariharan, David Bilder
Sep 19, 2006·Nature Genetics·Eunjoo ChoKenneth D Irvine
Feb 24, 2007·Nature Reviews. Cancer·Kieran Harvey, Nicolas Tapon
Apr 18, 2007·Genes & Development·Duojia Pan
Jul 12, 2007·Nature Reviews. Molecular Cell Biology·Leslie J Saucedo, Bruce A Edgar
Dec 26, 2007·The Journal of Biological Chemistry·Yawei HaoXiaolong Yang
Jan 30, 2008·Molecular and Cellular Biology·Qun-Ying LeiKun-Liang Guan
Feb 8, 2008·Development·Hyangyee Oh, Kenneth D Irvine
Mar 11, 2008·Current Biology : CB·Maria PraskovaJoseph Avruch
Jun 27, 2008·Genes & Development·Bin ZhaoKun-Liang Guan
Oct 29, 2008·Current Opinion in Cell Biology·Bin ZhaoKun-Liang Guan

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Citations

May 5, 2010·Genes & Development·Bin ZhaoKun-Liang Guan
Jun 15, 2011·PLoS Biology·Cordelia RauskolbKenneth D Irvine
Feb 23, 2013·Genes & Development·Fa-Xing Yu, Kun-Liang Guan
Jul 4, 2012·Seminars in Cell & Developmental Biology·Molly C Schroeder, Georg Halder
Mar 10, 2016·Developmental Cell·Hyung-Lok ChungKwang-Wook Choi
Dec 17, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Binnaz Kucuk Staley, Kenneth D Irvine
May 9, 2012·Journal of Cellular Biochemistry·Kuan-Min FangShun-Fen Tzeng
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·Yanlei MaHuanlong Qin
May 17, 2011·The Biochemical Journal·Alice Genevet, Nicolas Tapon
Dec 3, 2014·Developmental Biology·Hailey J KwonMadhuri Kango-Singh
Aug 30, 2012·Essays in Biochemistry·Nitin Sabherwal, Nancy Papalopulu
Jun 27, 2012·Developmental Biology·Xin YeZhi-Chun Lai
Oct 19, 2010·Developmental Cell·Duojia Pan
May 11, 2010·Trends in Cell Biology·Hyangyee Oh, Kenneth D Irvine
Sep 11, 2013·Biochemical and Biophysical Research Communications·Yifan Zhang, Zhi-Chun Lai
Jun 9, 2016·Trends in Cell Biology·Shuguo Sun, Kenneth D Irvine
May 24, 2016·Genes·Alexander Hergovich
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chiao-Lin ChenGeorg Halder
Mar 5, 2016·PLoS Genetics·Xiaona CuiYoufa Cheng
Apr 20, 2019·Developmental Neurobiology·Stephen F PolitanoPamela J Vanderzalm
Oct 1, 2015·Nature Communications·Shuguo SunKenneth D Irvine
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Juan Carlos Duhart, Laurel A Raftery
Oct 1, 2020·The Journal of Biological Chemistry·Thao TranJennifer M Kavran
Apr 29, 2011·Development·Beatriz García FernándezFlorence Janody
Jan 6, 2011·Genes & Development·Bin ZhaoKun-Liang Guan
May 5, 2011·Cellular Signalling·Alexander Hergovich
Jun 5, 2012·Trends in Cell Biology·Azucena Ramos, Fernando D Camargo

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