Mobile rRNA methylase genes coding for erythromycin resistance in Actinobacillus actinomycetemcomitans

The Journal of Antimicrobial Chemotherapy
D E RoeM C Roberts

Abstract

We found that 17 (68%) of 25 Actinobacillus actinomycetemcomitans isolated from periodontally diseased sites had MICs of erythromycin > or = 8 mg/L. The isolates were hybridized with five rRNA methylase genes and gene mobility was determined. Twenty-four (96%) of 25 isolates hybridized with one or more rRNA methylase genes. Representative isolates were able to transfer erythromycin resistance to Haemophilus influenzae and Enterococcus faecalis recipients. The transconjugants were shown to carry rRNA methylase genes by DNA probe hybridization and had MICs of erythromycin 32 to 256 mg/L.

Citations

Mar 12, 2002·FEMS Microbiology Letters·Si Young LeeJ Christopher Fenno
May 9, 1998·International Journal of Antimicrobial Agents·M C Roberts
Jun 25, 1999·The Journal of Antimicrobial Chemotherapy·W O ChungM C Roberts
Aug 1, 1995·Oral Microbiology and Immunology·D E RoeM C Roberts
Sep 7, 1999·Journal of Periodontology·I M MadinierL R Hannoun
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M C Roberts
May 10, 2017·Applied and Environmental Microbiology·Ajay M NarayananMarvin Whiteley
Dec 3, 1999·Antimicrobial Agents and Chemotherapy·M C RobertsH Seppala
Apr 4, 1998·Antimicrobial Agents and Chemotherapy·H SeppäläP Huovinen
Jul 1, 1996·Antimicrobial Agents and Chemotherapy·M C RobertsD E Roe

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