Mobility of NMDA autoreceptors but not postsynaptic receptors at glutamate synapses in the rat entorhinal cortex.

The Journal of Physiology
Jian YangRoland S G Jones

Abstract

NMDA receptors (NMDAr) are known to undergo recycling and lateral diffusion in postsynaptic spines and dendrites. However, NMDAr are also present as autoreceptors on glutamate terminals, where they act to facilitate glutamate release, but it is not known whether these receptors are also mobile. We have used functional pharmacological approaches to examine whether NMDA receptors at excitatory synapses in the rat entorhinal cortex are mobile at either postsynaptic sites or in presynaptic terminals. When NMDAr-mediated evoked EPSCs (eEPSCs) were blocked by MK-801, they showed no evidence of recovery when the irreversible blocker was removed, suggesting that postsynaptic NMDAr were relatively stably anchored at these synapses. However, using frequency-dependent facilitation of AMPA receptor (AMPAr)-mediated eEPSCs as a reporter of presynaptic NMDAr activity, we found that when facilitation was blocked with MK-801 there was a rapid (approximately 30-40 min) anomalous recovery upon removal of the antagonist. This was not observed when global NMDAr blockade was induced by combined perfusion with MK-801 and NMDA. Anomalous recovery was accompanied by an increase in frequency of spontaneous EPSCs, and a variable increase in frequency-fa...Continue Reading

References

Jan 24, 1989·European Journal of Pharmacology·M CincottaD Lodge
Feb 1, 1986·British Journal of Pharmacology·S G Agrawal, R H Evans
Mar 1, 2000·Biochemical and Biophysical Research Communications·A Fujita, Y Kurachi
Feb 27, 2001·Nature Neuroscience·J MeierD Choquet
Mar 17, 2001·Nature Reviews. Neuroscience·R H Scannevin, R L Huganir
Oct 16, 2001·Journal of Neurophysiology·G WoodhallR S Jones
Apr 24, 2002·Neuron·Kenneth R Tovar, Gary L Westbrook
Jun 7, 2002·Nature·Aren J Borgdorff, Daniel Choquet
Jun 8, 2002·Annual Review of Neuroscience·Roberto Malinow, Robert C Malenka
Oct 24, 2002·Trends in Neurosciences·Reed C Carroll, R Suzanne Zukin
Oct 24, 2002·Trends in Neurosciences·Insuk Song, Richard L Huganir
Apr 3, 2003·Nature Reviews. Neuroscience·Daniel Choquet, Antoine Triller
Oct 15, 2003·Neuron·David S Bredt, Roger A Nicoll
Jan 22, 2004·Nature Reviews. Neuroscience·Holly S Engelman, Amy B MacDermott
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rita BardoniAmy B MacDermott
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annalisa ScimemiDmitri A Rusakov
Jun 3, 2004·The Journal of Comparative Neurology·Michelle M AdamsJohn H Morrison
Jun 15, 2004·Current Opinion in Neurobiology·Yi NongMichael W Salter
Jun 29, 2004·Trends in Neurosciences·Brigitte van ZundertMartha Constantine-Paton
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip WashbourneA Kimberley McAllister
Nov 20, 2004·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel D Samson, Denis Paré
Mar 8, 2005·Trends in Neurosciences·Antoine Triller, Daniel Choquet

❮ Previous
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Citations

Apr 2, 2011·Endocrine·Fernando A GiulianiRicardo Cabrera
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas B GuardMihai Covasa
Nov 8, 2008·Neural Plasticity·Sophie E L ChamberlainRoland S G Jones
Feb 23, 2005·BMC Genomics·Christoph DieterichMartin Vingron
Sep 8, 2009·Trends in Neurosciences·Eric HanseLaurent Groc
Nov 26, 2015·Neuroscience·Guy BouvierPierre Paoletti
May 19, 2010·Journal of Neurochemistry·Luca Raiteri, Maurizio Raiteri
Nov 2, 2013·Seminars in Cell & Developmental Biology·Laurent LadépêcheLaurent Groc
Apr 8, 2011·Trends in Neurosciences·Dmitri A RusakovJeremy M Henley
Jul 30, 2014·Frontiers in Molecular Neuroscience·Osvaldo MiranteIsabelle M Mansuy
May 18, 2011·Neurobiology of Disease·Angelisa FrascaAnnamaria Vezzani
Jul 21, 2009·Neuropharmacology·Nicola H MorganGavin L Woodhall
Oct 16, 2008·The Journal of Physiology·Annalisa Scimemi
Feb 26, 2019·Frontiers in Neuroscience·Jinping LiuYan Wu

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