Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Hongru ZhaoJianqiang Ni

Abstract

The research aim was to investigate the effects of dl-3-n-butylphthalide (NBP) on the level of circulating endothelial progenitor cells (EPCs) and clinical outcome in patients with acute ischemic stroke (AIS). A total of 170 patients were included and randomly assigned to NBP group and control group. All patients were administrated a basic antiplatelet and lipid-lowering therapy. Among the patients, 86 received additional NBP administration for 30 days, whereas 84 received only basic therapy (the control). The level of circulating EPCs (marked with CD34(+)/CD133(+)/KDR(+)) was determined by flow cytometry at baseline and days 7, 14, and 30 after therapy. Impairment of neurological function was evaluated by the National Institutes of Health Stroke Scale (NIHSS) on days 7, 14, 30, and 90 after therapy. The association between the increased level of circulating EPCs and improvement of NIHSS score was evaluated by Pearson analysis. The clinical outcome was evaluated by modified Rankin Scale (mRS) on day 90. During the observation period, any adverse events related to drugs were reported. The levels of circulating EPCs on days 14 and 30 were significantly higher in the NBP group than in the control group. In contrast, NIHSS score wa...Continue Reading

References

Feb 15, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S H Graham, J Chen
Sep 1, 2007·Stroke; a Journal of Cerebral Circulation·Tomás SobrinoJosé Castillo
Dec 8, 2007·Stroke; a Journal of Cerebral Circulation·Hon-Kan YipHsueh-Wen Chang
Aug 14, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Akihiko TaguchiHiroaki Naritomi
Oct 22, 2009·British Journal of Clinical Pharmacology·Lindsey TillingBrian Clapp
Aug 25, 2010·Pharmacology & Therapeutics·L VellyP Pisano
May 28, 2011·Brain : a Journal of Neurology·Robert H AndresGary K Steinberg
Sep 9, 2011·The New England Journal of Medicine·Marc I ChimowitzUNKNOWN SAMMPRIS Trial Investigators
Feb 22, 2012·Circulation Research·Gian Paolo FadiniStefanie Dimmeler
Apr 21, 2012·Cerebrovascular Diseases·T G Liman, M Endres
Dec 13, 2012·CNS Neuroscience & Therapeutics·Yu-Hui ZhaoYan-Fang Chen

❮ Previous
Next ❯

Citations

May 16, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chuan QinYongting Wang
Jun 18, 2019·Chinese Medical Journal·Xi-Qian ChenWei Lu
Jan 6, 2017·BioMed Research International·Idriss Ali Abdoulaye, Yi Jing Guo
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Xiqian ChenWei Lu
Nov 22, 2020·Neurochemistry International·Bharath Chelluboina, Raghu Vemuganti
Jul 4, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ji LiDa-Wei Li
Jul 17, 2020·Journal of Medicinal Chemistry·José Marco-Contelles, Yihua Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Piotr KaźmierskiAndrzej Glabinski
Journal of Physiotherapy
Li Khim Kwah, Joanna Diong
© 2022 Meta ULC. All rights reserved