Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome

Journal of Cellular and Molecular Medicine
Alessia AlunnoMirko Manetti

Abstract

Although lymphatic neovascularization may be a key feature of chronic inflammation, it is almost unexplored in primary Sjögren's syndrome (pSS). A recent study revealed a pro-lymphangiogenic function of interleukin (IL)-17, a leading player in pSS pathogenesis. The aims of the study were to investigate lymphangiogenic mediators and lymphatic vasculature in pSS, as well as their possible association with IL-17. Circulating lymphatic endothelial precursor cells (LEPCs) and Th17 cells were enumerated in pSS patients and healthy donors. VEGF-C and IL-17 levels were assessed in paired serum samples. Lymphatic vasculature, VEGF-C/VEGF receptor (VEGFR)-3 and IL-17 were evaluated in pSS minor salivary glands (MSGs) and compared with normal and non-specific chronic sialadenitis (NSCS) MSGs. Circulating LEPCs were expanded in pSS and correlated with circulating Th17 cells, IL-17 and VEGF-C. In pSS MSGs, a newly formed lymphatic capillary network was found within periductal inflammatory infiltrates and the number of interlobular lymphatic vessels was significantly increased compared with normal and NSCS MSGs. Strong VEGF-C expression was detected in pSS ductal epithelial cells and periductal inflammatory cells. Numerous VEGFR-3(+) infiltr...Continue Reading

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Citations

Oct 14, 2018·Annals of the Rheumatic Diseases·Mirko ManettiMarco Matucci-Cerinic
Nov 9, 2018·BioMed Research International·Pollyana Ribeiro CastroLuciola Silva Barcelos
Jan 15, 2021·International Journal of Molecular Sciences·Clara ChivassoMuhammad Shahnawaz Soyfoo
Jun 3, 2021·International Journal of Molecular Sciences·Thi Hong Van Le, Sang-Mo Kwon

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Datasets Mentioned

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AB1875

Methods Mentioned

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biopsies
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flow cytometry

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Leica LAS
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