Mobilization of rat stomach ECL-cell histamine in response to short- or long-term treatment with omeprazole and/or YF 476 studied by gastric submucosal microdialysis in conscious rats

British Journal of Pharmacology
T KonagayaR Håkanson

Abstract

1. Mobilization of histamine from the ECL cells was monitored by gastric submucosal microdialysis in conscious rats. The ECL cells are known to operate under gastrin control and the purpose of the present study was to examine their in situ response to short-term (12 h) as well as long-term (28 days) hypergastrinaemia, induced by treatment with the proton pump inhibitor omeprazole. 2. Hypergastrinaemia promptly raised the histamine concentration in the microdialysate. The effect was prevented by CCK(2) receptor blockade (YF476). On day 7 of omeprazole treatment the microdialysate histamine concentration reached a peak, five times higher than before treatment. Subsequently (14 and 28 days), less histamine was mobilized. 3. Gastrin infusion (4 h) raised the microdialysate histamine concentration in a dose-dependent manner in fasted rats and freely fed rats and in rats treated with omeprazole for a week. However, while fasted and fed rats responded to low doses of gastrin, the omeprazole-treated rats required large doses of gastrin to respond. 4. When the amount of histamine mobilized was related to the serum gastrin concentration the following EC(50) values could be calculated: fasted rats 2.3 x 10(-10) M, freely fed rats 2.5 x 10...Continue Reading

References

Apr 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·A S KopinM Beinborn
Jun 14, 1991·Biochemical and Biophysical Research Communications·T ChibaS Hosoda
Oct 1, 1988·The Journal of Allergy and Clinical Immunology·A M Morel, M A Delaage
May 14, 1999·General Pharmacology·D ChenR Håkanson
Jun 29, 1999·British Journal of Pharmacology·E LindströmR Håkanson

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Citations

Apr 28, 2007·Journal of Gastroenterology·Hiroshi HashimotoKazuyoshi Hirota
Apr 28, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nele Plock, Charlotte Kloft
Oct 13, 2006·Current Opinion in Gastroenterology·Mitchell L Schubert
May 6, 2004·Basic & Clinical Pharmacology & Toxicology·Gunnar Qvigstad, Helge Waldum

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