PMID: 8597912Dec 1, 1995Paper

Mock drug delivery to the proximal aorta during cardiopulmonary resuscitation: central vs peripheral intravenous infusion with varying flush volumes

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
G M GaddisM L Gaddis

Abstract

To compare mock drug deliveries to the proximal aorta during CPR after peripheral vs central i.v. administration when the mock drug is followed by different postinfusion flush volumes. Delivery of indocyanine green (ICG) dye to the proximal aorta of an instrumented 20-kg canine cardiac arrest model was examined. The ICG administration (2.5 mg) preceded either a 2-mL or a 10-mL saline flush, for either a central or a peripheral i.v. route of dye administration. Five dogs each underwent three sets of the four possible route/flush-volume combinations in a stratified randomized order. Real-time dye-absorbance-vs-time curves, as sampled from the proximal aorta, modeled central-circulation drug delivery. Systolic and diastolic blood pressures (BPs) were monitored, and the absorbance-vs-time curve upstroke phases were used to estimate cardiac output during arrest. Times (mean +/- SD) to onset of dye appearance did not differ significantly between peripheral/10 mL (126 +/- 35 sec) and central/10 mL (108 +/- 35 sec), or between central/2 mL (123 +/- 31 sec) and central/10 mL. Times to onset of dye appearance did differ between peripheral/2 mL (161 +/- 70 sec) and central/10 mL [analysis of variance (ANOVA) p = 0.032]. Times to peak dye ...Continue Reading

References

May 1, 1990·The American Journal of Emergency Medicine·C L EmermanJ F Hagen
Nov 1, 1988·Critical Care Medicine·C L EmermanJ F Hagen
Sep 1, 1984·The American Journal of Emergency Medicine·J R HedgesH Nishiyama
Aug 1, 1981·Annals of Emergency Medicine·G J KuhnP J Hoehner
Jul 1, 1963·The American Journal of Cardiology·A BENCHIMOLM W ROBERTS

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Citations

Feb 16, 2012·Journal of the American Veterinary Medical Association·Manuel BollerCynthia M Otto
Mar 16, 2021·Journal of Feline Medicine and Surgery·Melody J WardRebecca A Walton

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