PMID: 8961036Nov 25, 1996Paper

Moclobemide and fluoxetine in treatment of seasonal affective disorder

Journal of Affective Disorders
T Partonen, J Lonnqvist

Abstract

Of a total of 581 consecutive depressed subjects attending psychiatric services of 6 centres in Finland, 183 patients were eligible and completed a 6-week randomised double-blind trial with either moclobemide or fluoxetine. Of these, 32 (17.5%) patients met the DSM-III-R criteria for mood disorder with a seasonal (winter) pattern and 19 patients (10.5%) met the original criteria for seasonal affective disorder (SAD). There were no significant difference in the antidepressive response to the treatment between the patients with SAD and other depressive disorder. The treatment of 6 weeks with either moclobemide (300-450 mg daily) or fluoxetine (20-40 mg daily) resulted in a full remission in 15 (52%) patients with SAD and in 44 (37%) patients with other depressive disorder. Altogether, 23 (79%) and 83 (70%) patients, respectively, got significant benefit from the treatment. The improvement in the health-related quality of life in terms of ability to work was significantly more extensive in the patients with SAD assigned to receive moclobemide compared with the other depressive patients allocated to the same medication. Subjects who in addition met the operational criteria for atypical depression were equally distributed into the S...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
May 1, 1992·Biological Psychiatry·A C PandeJ F Greden
May 1, 1995·Acta Psychiatrica Scandinavica·B E ThalénL Wetterberg
Jan 1, 1995·Comprehensive Psychiatry·D SchlagerA Jaffe
Feb 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·P A ChildsC Thompson
Nov 1, 1994·Journal of Affective Disorders·J LonnqvistO Kiviruusu
Aug 1, 1993·Acta Psychiatrica Scandinavica·O Lingjaerde, T Reichborn-Kjennerud
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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Citations

Nov 13, 2004·Current Psychiatry Reports·Chang-Ho Sohn, Raymond W Lam
Feb 6, 2010·Médecine sciences : M/S·Anne-Marie GagnéMarc Hébert
Oct 12, 2007·CNS Drugs·Asa Westrin, Raymond W Lam
Jul 17, 2007·Primary Care Companion to the Journal of Clinical Psychiatry
Nov 5, 1998·Lancet·T Partonen, J Lönnqvist
Feb 21, 2009·Journal of Psychosocial Nursing and Mental Health Services·Robert H Howland
May 10, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·F Benazzi
Mar 23, 2007·Psychiatry Research·Anne-Marie GagnéMarc Hébert
Nov 8, 2005·Biological Psychiatry·Jack G ModellDonna S Wightman
Dec 15, 2015·Indian Journal of Psychological Medicine·Arshad HussainTariq Ahmad Bhat
May 28, 2013·Expert Opinion on Drug Metabolism & Toxicology·Peter NiemegeersBernard G C Sabbe
Jan 6, 2010·The Physician and Sportsmedicine·Robert H Howland
Nov 26, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne-Marie GagnéMarc Hébert
Dec 3, 2005·Psychiatry Research·Verena HenkelUlrich Hegerl
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Kylie ThalerGerald Gartlehner
Jul 27, 2018·Expert Opinion on Pharmacotherapy·Olivia CoolsBernard Sabbe
Jul 13, 2006·Expert Review of Neurotherapeutics·Dietmar WinklerSiegfried Kasper
Jul 15, 2015·Reviews in the Neurosciences·Alexander V Kulikov, Nina K Popova
Feb 22, 2003·CNS Drug Reviews·Udo Bonnet
Oct 25, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·V K DewanIsha Dewan
Dec 16, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·George I Papakostas, Maurizio Fava
Jul 26, 2005·CNS Spectrums·Edda PjrekSiegfried Kasper
Mar 5, 2021·The Cochrane Database of Systematic Reviews·Barbara Nussbaumer-StreitGerald Gartlehner

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