Modafinil and sleep architecture in an inpatient-outpatient treatment study of cocaine dependence

Drug and Alcohol Dependence
P T MorganE Forselius

Abstract

To determine whether the increase in slow-wave sleep associated with modafinil treatment in chronic cocaine users mediates improved clinical outcomes. 57 cocaine dependent participants were randomized to receive modafinil 400mg or placebo daily during a period of inpatient treatment followed by six weeks of outpatient treatment. Participants underwent polysomnographic sleep recording during inpatient treatment prior to and after starting modafinil. Outpatient treatment consisted of weekly cognitive behavioral therapy. Contingency management was used to promote participation in treatment and research demands, including thrice weekly visits during the outpatient phase for urine toxicology screens and other assessments. The primary clinical outcome was the percent of urine toxicology screens that were negative for cocaine. Modafinil treatment was associated with a higher mean percentage (52% vs. 26%) of cocaine-free urine screens (p=0.02) and an increase in N3 sleep time (p=0.002). The change in N3 sleep time mediated the higher rate of cocaine-free urine screens. Modafinil treatment was also associated with more consecutive days abstinent during outpatient treatment, greater survival of abstinence, higher daily rates of abstinenc...Continue Reading

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Citations

Mar 30, 2017·Substance Use & Misuse·Dinesh SangroulaSteven Lippmann
Jan 18, 2020·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Ana Sousa, Ricardo Jorge Dinis-Oliveira
Apr 28, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maddalena MereuGianluigi Tanda
Aug 26, 2019·Psychopharmacology·Christina Gobin, Marek Schwendt
Sep 10, 2020·Journal of Clinical Medicine·Carlos RonceroLourdes Aguilar
Feb 15, 2021·Pharmacology, Biochemistry, and Behavior·Timothy RoehrsThomas Roth
Mar 13, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Mark K GreenwaldTimothy A Roehrs
Jun 15, 2021·Frontiers in Neuroscience·Melinda HerseyGianluigi Tanda

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