Mode-dependent effect of high-frequency electrical stimulation of the anterior thalamic nucleus on amygdala-kindled seizures in rats

Neuroscience
Q ZhangLan Tan

Abstract

Deep brain stimulation (DBS) is an emerging treatment of epilepsy. Anterior nucleus of the thalamus (ANT) is considered to be an attractive target due to its close connection to the limbic structures and wide regions of neocortex. The present study aimed to investigate the effects of high frequency stimulation (HFS) targeting the ANT on amygdala-kindled seizures in Wistar rats in two different stimulation modes i.e. pre-treatment and post-treatment stimulations, mimicking the scheduled and responsive stimulations in clinical use respectively. When fully-kindled seizures were achieved by daily amygdala kindling (1 s train of 1 ms pulses at 60 Hz), HFS (15 min train of 100 μs pulses at 150 Hz and 450-800 μA) was applied in two modes for 10 days. Bilateral post-treatment with HFS reduced the incidence of generalized seizures and the mean behavioral seizure stage and shortened average afterdischarge duration (ADD) and generalized seizure duration (GSD), while bilateral pre-treatment with HFS resulted in a similar but much weaker inhibition of seizures. On the other hand, we also found the two stimulation modes both increased the afterdischarge threshold (ADT) and the differences of current intensity between ADT and generalized seiz...Continue Reading

References

Apr 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·K Gale
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
Jun 13, 2002·Epilepsia·Mojgan HodaieAndres M Lozano
Jan 25, 2005·Acta neurochirurgica·C HamaniA M Lozano
Jan 26, 2005·Annals of Neurology·Ivan OsorioSteven B Wilkinson
Mar 28, 2007·Epilepsia·Ivan OsorioSteven B Wilkinson
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Felice T SunRobert E Wharen
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Paul BoonKristl Vonck
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Juan A Barcia, José M Gallego
Jul 22, 2010·Epilepsia·Barbara C JobstDavid W Roberts
Jul 22, 2010·Epilepsia·Premysl JiruskaJohn G R Jefferys
Sep 16, 2010·Current Treatment Options in Neurology·Barbara C Jobst
Apr 5, 2011·Brain Research Bulletin·Xiao-Ling ZhongLan Tan
Sep 16, 2011·Neurology·Martha J Morrell, UNKNOWN RNS System in Epilepsy Study Group
Sep 24, 2011·Neurosurgery Clinics of North America·Paul R Gigante, Robert R Goodman

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Citations

Mar 31, 2016·Neuroscience and Biobehavioral Reviews·D C W KloosterP Boon
Jun 23, 2015·Computer Methods and Programs in Biomedicine·Vicente PallarésDavid Moratal
Oct 23, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jing ShiGuo-Feng Wu

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