Mode of action of novel polyamines increasing the permeability of bacterial outer membrane

International Journal of Antimicrobial Agents
Keiko YasudaTakashi Katsu

Abstract

We have clarified how the polyamines naphthylacetylspermine and methoctramine (N,N'-bis[6-[[(2-methoxyphenyl)methyl]amino]hexyl]-1,8-octanediamine), originally developed as a synthetic analogue of joro spider toxin and a muscarinic receptor antagonist, respectively, can increase the permeability of the outer membrane of Escherichia coli. These polyamines were recently found to be outer membrane permeabilisers, based on investigations of the structure-activity relationship using ion-selective electrodes. In a standard microbiological assay examining membrane-permeabilising ability, these polyamines enhanced the action of hydrophobic antibiotics such as novobiocin and erythromycin, which ineffectively traverse the outer membrane of E. coli, to inhibit the growth of E. coli. This result substantiated the outer membrane-permeabilising ability of these polyamines demonstrated by using ion-selective electrodes. We observed the release of lipopolysaccharide from the outer membrane in the concentration range causing permeabilisation, showing that the action of the polyamines is attributable to disruption of the outer membrane structure.

References

Jul 1, 1990·Medicinal Research Reviews·C Melchiorre
May 27, 1980·Biochimica Et Biophysica Acta·A J Wicken, K W Knox
Nov 1, 1995·Antimicrobial Agents and Chemotherapy·S RadulovicA F Azad
Jan 1, 1997·Trends in Microbiology·R E Hancock
Jan 16, 1999·Biochemical Pharmacology·J M Schröder
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Takashi KatsuKeiko Yasuda
Nov 26, 2002·FEMS Microbiology Letters·Paul B SavageQunying Guan

❮ Previous
Next ❯

Citations

Feb 24, 2006·Antimicrobial Agents and Chemotherapy·Rajalakshmi BalakrishnaSunil A David
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Dong H Kwon, Chung-Dar Lu
Nov 14, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Chanaz SalmiJean Michel Brunel
Aug 10, 2007·Expert Opinion on Investigational Drugs·Chanaz Salmi, Jean M Brunel
Sep 17, 2004·Journal of Microbiological Methods·Chie OhmizoTakashi Katsu
May 27, 2016·Future Medicinal Chemistry·Marine BlanchetJean Michel Brunel
Apr 21, 2019·Medicinal Research Reviews·Andraž LamutTihomir Tomašič
Apr 8, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Keiko KomagoeTakashi Katsu
May 27, 2017·International Journal of Microbiology·E Escamilla-GarcíaM Márquez
Jan 31, 2020·Frontiers in Microbiology·Abraham Espinoza-CulupúMonamaris Marques Borges
May 8, 2019·Journal of Medicinal Chemistry·Hana DouaferJean Michel Brunel
Apr 28, 2020·Biochimica Et Biophysica Acta. Biomembranes·Jianguo LiChandra S Verma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Expert Opinion on Investigational Drugs
Chanaz Salmi, Jean M Brunel
FEMS Microbiology Letters
Paul B SavageQunying Guan
Proceedings of the National Academy of Sciences of the United States of America
Manas K ChattopadhyayHerbert Tabor
© 2022 Meta ULC. All rights reserved