Mode of action of pesticin.

Journal of Bacteriology
M Elgat, R Ben-Gurion

Abstract

The mode of action of pesticin, a bacteriocin produced by many strains of Pasturella pestis, was studied. Pesticin action on macromolecular synthesis of a sensitive strain of Escherichia coli, strain phi, was found to have features similar to those of colicin E2-317 acting on the same strain. After exposure to pesticin, deoxyribonucleic acid synthesis was arrested and ribonucleic acid was degraded, but little effect was observed on protein synthesis. Pesticin, like colicin E2-317, induced lysogenic E. coli phi (P1), but, unlike the colicin, was active in the presence of dinitrophenol. Trypsin was found to reverse pesticin action up to 15 min after its addition at 40 C to E. coli phi. Pesticin action was studied on three sensitive bacterial strains, P. pestis 2C, P. pseudotuberculosis, and E. coli strain phi, which vary widely in their optimal growth temperature. P. pestis grows best at 29 C, P. pseudotuberculosis at 37 C, and E. coli phi at 40 C. It was found that pesticin action on all three strains was optimal at 40 C. Whereas the titer of pesticin was the same on all three strains when determined on agar, E. coli phi was the most sensitive to pesticin action in broth. No action of pesticin in broth on P. pseudotuberculosis w...Continue Reading

References

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Citations

Jan 1, 1990·Folia Microbiologica·J SmardaZ Vrbická
Mar 10, 2007·Microbiology and Molecular Biology Reviews : MMBR·Eric CascalesDanièle Cavard
Oct 1, 1970·Journal of Bacteriology·J S Ellison, J A Kautter
Feb 1, 1992·Research in Microbiology·L M FariasE C Vieira
Aug 1, 1979·Journal of Bacteriology·D M Ferber, R R Brubaker
Jul 1, 1991·Clinical Microbiology Reviews·R R Brubaker
Mar 1, 1984·Infection and Immunity·T Une, R R Brubaker
Oct 1, 1972·Journal of Bacteriology·P C HuR R Brubaker
Dec 1, 1979·Antimicrobial Agents and Chemotherapy·K G MossieD R Woods
Sep 30, 1970·Biochemical and Biophysical Research Communications·R Ben-Gurion

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