Mode of conception does not appear to affect placental volume in the first trimester

Fertility and Sterility
Sara J ChurchillMargareta D Pisarska

Abstract

To study whether infertility treatments, including IVF and non-IVF fertility treatments, are associated with diseases of placental insufficiency in early gestation. First trimester placental volumes by ultrasound and chorionic villi weight during sampling (CVS) were performed to detect differences between pregnancies conceived spontaneously versus with fertility treatments. Retrospective cohort. Academic tertiary center. Women with singleton pregnancies undergoing CVS and first trimester ultrasound from April 2007 to November 2015. Estimated placental volume (EPV) was calculated from ultrasound images using a validated computation and CVS estimated tissue weight was performed using a validated visual analogue scale. Adjusted linear regression was used to compare EPV and CVS weight based on mode of conception. A total of 1,977 spontaneous and 334 conceived with fertility treatments (133 non-IVF and 201 IVF) pregnancies were included. Significant differences in maternal age, gravidity, hypertension, and smoking status were identified. EPV and CVS weight were correlated with maternal age, gestational age, and maternal hypertension. Adjusted linear regression showed no difference in EPV in pregnancies conceived with fertility treat...Continue Reading

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