Mode of delivery in hemophilia: vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds

Haematologica
Nadine G AnderssonPedNet Haemophilia Research Foundation

Abstract

The optimal mode of delivery for a pregnant hemophilia carrier is still a matter of debate. The aim of the study was to determine the incidence of intracranial hemorrhage and other major bleeds in neonates with moderate and severe hemophilia in relationship to mode of delivery and known family history. A total of 926 neonates, 786 with severe and 140 with moderate hemophilia were included in this PedNet multicenter study. Vaginal delivery was performed in 68.3% (n=633) and Cesarean section in 31.6% (n=293). Twenty intracranial hemorrhages (2.2%) and 44 other major bleeds (4.8%) occurred. Intracranial hemorrhages occurred in 2.4% of neonates following vaginal delivery compared to 1.7% after Cesarean section (P=not significant); other major bleeds occurred in 4.2% born by vaginal delivery and in 5.8% after Cesarean section (P=not significant). Further analysis of subgroups (n=813) identified vaginal delivery with instruments being a significant risk factor for both intracranial hemorrhages and major bleeds (Relative Risk: 4.78-7.39; P<0.01); no other significant differences were found between vaginal delivery without instruments, Cesarean section prior to and during labor. There was no significant difference in frequency for intr...Continue Reading

Associated Clinical Trials

Citations

Jun 10, 2020·Expert Review of Clinical Pharmacology·Massimo Morfini, Emanuela Marchesini
Aug 26, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Alice NauBrigitte Pan-Petesch
Sep 29, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Roseline d'OironAndra H James
Jul 1, 2020·European Journal of Haematology·Michelle LavinBridgette Byrne
Jun 11, 2020·British Journal of Haematology·Nadine G AnderssonUNKNOWN ICH study group
Dec 15, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Eveline P Mauser-BunschotenKarin P M van Galen
Jun 5, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Jane A Mason, Guy Young
Jun 10, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·Shadan LalezariGili Kenet
Sep 22, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Maria Elisa MancusoKarin Fijnvandraat

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Methods Mentioned

BETA
Cesarean section

Software Mentioned

SPSS Statistics
R

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