PMID: 8450262Apr 1, 1993Paper

Mode of inoculation of the Lyme disease agent Borrelia burgdorferi influences infection and immune responses in inbred strains of mice

The Journal of Infectious Diseases
L GernM M Simon

Abstract

Mice were infected with Borrelia burgdorferi by infection via Ixodes ricinus and experimental inoculation to determine whether transmission rates of spirochetes and antibody responses are influenced. Mice infected by the natural route were substantially more infective for ticks; two- to sixfold more tick larvae were positive for B. burgdorferi than those fed on experimentally inoculated mice. In natural infection, spirochetemia may be greater or spirochetes may be more accessible for transmission. Thus, this form of xenodiagnosis could be used to determine levels of spirochetes in the vertebrate host. Similar levels of antibody were present in all mice; however, those infected by the natural route lacked antibodies to outer surface proteins (Osp) A and B. The small antigen dose given through a tick bite may not have been sufficient to induce rapid OspA or OspB antibodies, thereby allowing the later development of higher levels of spirochetemia.

Citations

Jul 21, 2004·Folia Microbiologica·L Kovár
Apr 28, 2004·Medical Microbiology and Immunology·Sharon LedererMarkus M Simon
Jul 1, 1997·Parasitology Today·A M De Silva, E Fikrig
Mar 21, 1998·Trends in Microbiology·M T Philipp
May 3, 2005·Nature Reviews. Microbiology·Sean E Connolly, Jorge L Benach
Feb 25, 2010·The Journal of Biological Chemistry·Jing WuHaining Yu
Jun 24, 2010·Vector Borne and Zoonotic Diseases·Lisa E SchwanzRichard S Ostfeld
Aug 3, 2012·Clinical and Vaccine Immunology : CVI·Brian T CampfieldAndrew J Nowalk
May 24, 2005·Infection and Immunity·Emir HodzicStephen W Barthold
Aug 23, 2000·The Journal of Clinical Investigation·U PalE Fikrig
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J OhnishiA M de Silva
Aug 27, 2002·Folia Parasitologica·Jitka PechováJan Kopecký
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·W ZhongM M Simon
Jul 5, 2005·Expert Opinion on Investigational Drugs·W T Thanassi, R T Schoen
Jun 25, 1998·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·S Leuba-GarciaL Gern
Jun 15, 2004·Microbial Pathogenesis·Fang Ting LiangErol Fikrig
Jun 21, 2005·Microbial Pathogenesis·Jennifer C MillerAndrew R Pachner
Oct 9, 2014·Parasitology·Maarten J Voordouw
Sep 7, 2004·Annals of Neurology·Andrew R PachnerDiego Cadavid
Mar 28, 2003·The Journal of Parasitology·Z KrocováJ Kopecký
Jun 15, 2006·The Journal of Biological Chemistry·Michalis KotsyfakisJosé M C Ribeiro
Aug 3, 2018·Proceedings. Biological Sciences·Claire CayolEsa Koskela
Sep 22, 2019·Applied and Environmental Microbiology·Andrea Gomez-ChamorroMaarten J Voordouw
Apr 15, 2000·Annals of Internal Medicine·W T Thanassi, R T Schoen
Jul 12, 2017·Frontiers in Cellular and Infection Microbiology·Ladislav ŠimoSarah I Bonnet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.