Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes

Proceedings of the National Academy of Sciences of the United States of America
Shirly Miniowitz-ShemtovAvram Hershko

Abstract

The AAA-ATPase thyroid hormone receptor interacting protein 13 (TRIP13), jointly with the Mad2-binding protein p31(comet), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC). This checkpoint system ensures the accuracy of chromosome segregation by delaying anaphase until correct bipolar attachment of chromatids to the mitotic spindle is achieved. MCC inhibits the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets for degradation securin, an inhibitor of anaphase initiation. MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3, in association with the APC/C activator Cdc20. The assembly of MCC in active checkpoint is initiated by the conversion of Mad2 from an open (O-Mad2) to a closed (C-Mad2) conformation, which then binds tightly to Cdc20. Conversely, the disassembly of MCC that takes place when the checkpoint is turned off involves the conversion of C-Mad2 back to O-Mad2. Previously, we found that the latter process is mediated by TRIP13 together with p31(comet), but the mode of their interaction remained unknown. Here, we report that the oligomeric form of TRIP13 binds both p31(comet) and MCC. Furthermore, p31(co...Continue Reading

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Citations

Jan 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sharon KaisariAvram Hershko
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jianhui JiZhukuan Cheng
Jul 8, 2017·The Journal of Cell Biology·Samuel Gilberto, Matthias Peter
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Jul 23, 2020·Molecular Biology of the Cell·Lénaïg DéfachellesNeedhi Bhalla
Jan 29, 2019·Frontiers in Cell and Developmental Biology·Weimei RuanUttam Surana
May 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sharon KaisariAvram Hershko
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sharon KaisariAvram Hershko
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Aug 18, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Toshiyuki Habu, Jiyeong Kim

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