Abstract
The AAA-ATPase thyroid hormone receptor interacting protein 13 (TRIP13), jointly with the Mad2-binding protein p31(comet), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC). This checkpoint system ensures the accuracy of chromosome segregation by delaying anaphase until correct bipolar attachment of chromatids to the mitotic spindle is achieved. MCC inhibits the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets for degradation securin, an inhibitor of anaphase initiation. MCC is composed of the checkpoint proteins Mad2, BubR1, and Bub3, in association with the APC/C activator Cdc20. The assembly of MCC in active checkpoint is initiated by the conversion of Mad2 from an open (O-Mad2) to a closed (C-Mad2) conformation, which then binds tightly to Cdc20. Conversely, the disassembly of MCC that takes place when the checkpoint is turned off involves the conversion of C-Mad2 back to O-Mad2. Previously, we found that the latter process is mediated by TRIP13 together with p31(comet), but the mode of their interaction remained unknown. Here, we report that the oligomeric form of TRIP13 binds both p31(comet) and MCC. Furthermore, p31(co...Continue Reading
References
Jul 13, 2000·The Journal of Cell Biology·R D Vale
Jul 28, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T Ogura, A J Wilkinson
Nov 29, 2002·The EMBO Journal·Toshiyuki HabuTomohiro Matsumoto
Jul 17, 2004·The EMBO Journal·Guohong XiaHongtao Yu
Aug 3, 2005·Nature Reviews. Molecular Cell Biology·Phyllis I Hanson, Sidney W Whiteheart
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ilana BraunsteinAvram Hershko
Apr 12, 2007·Nature Reviews. Molecular Cell Biology·Andrea Musacchio, Edward D Salmon
Feb 5, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kevin L Y CheungJoaquin Ortega
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shirly Miniowitz-ShemtovAvram Hershko
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Adar TeichnerAvram Hershko
Mar 23, 2012·Nature·William C H ChaoDavid Barford
Jun 21, 2012·BMC Cell Biology·Aaron R TiptonSong-Tao Liu
Sep 25, 2012·Nucleic Acids Research·Andrés López-PerroteOscar Llorca
Nov 24, 2012·Current Biology : CB·Pablo Lara-GonzalezStephen S Taylor
Apr 20, 2013·Trends in Biochemical Sciences·Luying JiaHongtao Yu
Jul 12, 2014·The Journal of Biological Chemistry·Kexi WangSong-Tao Liu
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Esther EytanAvram Hershko
Sep 2, 2014·Current Opinion in Structural Biology·Leifu Chang, David Barford
Apr 29, 2015·ELife·Qiaozhen YeKevin D Corbett
May 6, 2015·ELife·Maximina H YunJeremy P Brockes
Citations
Jan 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sharon KaisariAvram Hershko
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jianhui JiZhukuan Cheng
Nov 22, 2016·Biology·Ajit P Joglekar
Mar 4, 2017·Scientific Reports·Jeffrey D PresslyFrank Park
Jul 8, 2017·The Journal of Cell Biology·Samuel Gilberto, Matthias Peter
Dec 1, 2017·Nucleic Acids Research·Alan M V WestKevin D Corbett
Dec 9, 2016·American Journal of Physiology. Renal Physiology·Jeffrey D Pressly, Frank Park
Dec 7, 2017·Nature Communications·Melissa L BrulotteXuelian Luo
Oct 7, 2017·The FEBS Journal·Inai ParkHyunsook Lee
Jun 9, 2018·PloS One·Scott C SchuylerVivien Cheng
Sep 4, 2016·Biology Open·Dimitriya H GarvanskaJakob Nilsson
Aug 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Alessandro A RizzoDmitry M Korzhnev
Jul 1, 2017·The EMBO Journal·Qiaozhen YeKevin D Corbett
Nov 2, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sutherland K Maciver
Feb 6, 2017·Oncotarget·Yi TaoJumei Shi
Jul 10, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Paulo G HofstatterDaniel J G Lahr
Jul 31, 2020·PLoS Genetics·Stefani GiacopazziNeedhi Bhalla
Jul 23, 2020·Molecular Biology of the Cell·Lénaïg DéfachellesNeedhi Bhalla
Jan 29, 2019·Frontiers in Cell and Developmental Biology·Weimei RuanUttam Surana
May 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sharon KaisariAvram Hershko
Jul 23, 2020·Cancer Cell International·Fengling ChenShuya Wang
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sharon KaisariAvram Hershko
Oct 21, 2018·Nature Communications·Dong Hyun KimDon W Cleveland
Nov 3, 2020·Cancer Biomarkers : Section a of Disease Markers·Weiyang CaiYanyan Li
Oct 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Prabha SarangiAlan D D'Andrea
Mar 14, 2021·Current Genetics·Richard Cardoso da Silva, Gerben Vader
May 20, 2020·Current Biology : CB·Geert J P L KopsEelco C Tromer
Jun 2, 2021·Environmental Toxicology·Xiaoying LiuJing Zhang
Jun 11, 2021·Frontiers in Cell and Developmental Biology·Tatyana BodrugNicholas G Brown
Jun 27, 2021·The Journal of Biological Chemistry·Chloe Du TruongRajiv Kumar
Aug 18, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Toshiyuki Habu, Jiyeong Kim
Nov 23, 2021·JCI Insight·Taketsugu HamaFrank Park