Mode of nitric oxide delivery affects antibacterial action.

ACS Biomaterials Science & Engineering
Jackson R HallMark H Schoenfisc

Abstract

Nitric oxide (NO) is a broad-spectrum antibacterial agent, making it an attractive alternative to traditional antibiotics for treating infections. To date, a direct comparison of the antibacterial activity of gaseous NO (gNO) versus water-soluble NO-releasing biopolymers has not been reported. In this study, the bactericidal action of NO-releasing chitosan oligosaccharides was compared to gNO treatment against cystic fibrosis-relevant Gram-positive and Gram-negative bacteria. A NO exposure chamber was constructed to enable the dosing of bacteria with gNO at concentrations up to 800 ppm under both aerobic and anaerobic conditions. Bacteria viability, solution properties (i.e., pH, NO concentration), and toxicity to mammalian cells were monitored to ensure a thorough understanding of bactericidal action and reproducibility for each delivery method. The NO-releasing chitosan oligosaccharides required significantly lower NO doses relative to gNO therapy to elicit antibacterial action against Pseudomonas aeruginosa and Staphylococcus aureus under both aerobic and anaerobic conditions. Reduced NO doses required for bacteria eradication using water-soluble NO-releasing chitosan were attributed to the release of NO in solution, removin...Continue Reading

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Citations

Mar 25, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kaitlyn R RouillardMark H Schoenfisch
Mar 7, 2021·Biomolecules·Allison M RiceS Bruce King
Nov 13, 2020·Drug Discovery Today·Laurent R ChiarelliMaria Rosalia Pasca
May 4, 2021·Applied Microbiology and Biotechnology·Yu-Ming CaiLiang Yang
May 4, 2021·The Ocular Surface·Shyam Sunder TummanapalliMark D P Willcox
Jul 10, 2021·Bioorganic & Medicinal Chemistry Letters·Allison M RiceS Bruce King
Jun 9, 2020·ACS Infectious Diseases·Kaitlyn R RouillardMark H Schoenfisch
Dec 10, 2020·ACS Infectious Diseases·Kaitlyn R RouillardMark H Schoenfisch

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