PMID: 7032452Mar 1, 1981Paper

Mode of proliferation of gonadotrophic cells of the anterior pituitary after castration--immunocytochemical and autoradiographic studies

Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku
K Inoue, K Kurosumi

Abstract

There are three possibilities concerning the mechanism of increase in number of gonadotrophs in the anterior pituitary after castration: one is the cell division by mitosis of matured gonadotrophs, another is the differentiation of immature cells, and the third is conversion of some other cell types into gonadotrophs. In order to determine the above possibilities, light and electron microscopic examinations using a combination of immunocytochemistry and autoradiography were performed. Normal and castrated adult male rats were used. Morphometry indicated that a highly increased population of gonadotrophs reacted with anti-LH beta serum after castration. Increased numbers of mitoses and elevated incorporation of 3H-thymidine into the nuclear chromatin were observed in both anti-LH beta reactive cells and other pituitary cells after castration. Electron microscopic immunocytochemical observations demonstrated the presence of immature cells with a few immunoreactive secretory granules in the castrated pituitary. It is considered that mitosis is a major factor for proliferation of gonadotrophs in the anterior pituitary after castration, but the possibility of differentiation from immature cells into gonadotrophs cannot be ruled out....Continue Reading

Citations

Aug 1, 1990·Cell and Tissue Research·E Carbajo-Pérez, Y G Watanabe
Sep 1, 1991·Journal of Electron Microscopy Technique·K Kurosumi
Apr 1, 1988·Journal of Electron Microscopy Technique·E Horvath, K Kovacs
Mar 18, 2006·Molecular Endocrinology·Michael A CharlesDavid F Gordon
Sep 19, 2019·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Adrian FloreaMarius Cristian Oprea

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