Model and cell membrane partitioning of perfluorooctanesulfonate is independent of the lipid chain length.

Colloids and Surfaces. B, Biointerfaces
Wei XieHans-Joachim Lehmler

Abstract

Perfluorooctanesulfonic acid (PFOS) is a persistent environmental pollutant that may cause adverse health effects in humans and animals by interacting with and disturbing of the normal properties of biological lipid assemblies. To gain further insights into these interactions, we investigated the effect of PFOS potassium salt on dimyristoyl- (DMPC), dipalmitoyl- (DPPC) and distearoylphosphatidylcholine (DSPC) model membranes using fluorescence anisotropy measurements and differential scanning calorimetry (DSC) and on the cell membrane of HL-60 human leukemia cells and freshly isolated rat alveolar macrophages using fluorescence anisotropy measurements. PFOS produced a concentration-dependent decrease of the main phase transition temperature (T(m)) and an increased peak width (DeltaT(w)) in both the fluorescence anisotropy and the DSC experiments, with a rank order DMPC>DPPC>DSPC. PFOS caused a fluidization of the gel phase of all phosphatidylcholines investigated, but had the opposite effect on the liquid-crystalline phase. The apparent partition coefficients of PFOS between the phosphatidylcholine bilayer and the bulk aqueous phase were largely independent of the phosphatidylcholine chain length and ranged from 4.4x10(4) to 8....Continue Reading

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May 9, 2012·Analytical and Bioanalytical Chemistry·Arno C GutlebJean-Nicolas Audinot
Jul 28, 2012·The Journal of Physical Chemistry. B·E Davis OldhamHans-Joachim Lehmler
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Jul 15, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Limin ZhangJeffrey M Peters
Dec 23, 2016·The Journal of Toxicological Sciences·Shuji Tsuda
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Aug 29, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anthony J F ReardonElla Atlas

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