Model-based analysis of trial data: microfilaria and worm-productivity loss after diethylcarbamazine-albendazole or ivermectin-albendazole combination therapy against Wuchereria bancrofti

Tropical Medicine & International Health : TM & IH
Marlieke E A de KrakerJ D Habbema

Abstract

To determine the efficacies of combinations of ivermectin or diethylcarbamazine and albendazole, which are recommended for use in mass treatment programmes against lymphatic filariasis. Review of published trends in microfilarial (mf) intensities after treatment with these combination therapies. By fitting a mathematical model of treatment effects to the trial data, we quantified the efficacy of treatment, distinguishing between the killing of mf (mf loss) and a reduction in mf production by adult worms (worm-productivity loss). After diethylcarbamazine-albendazole treatment mf density dropped immediately, then slowly but steadily decreased further (four trials). After ivermectin-albendazole treatment, mf densities immediately dropped to near-zero levels, followed by a small increase (five trials). For diethylcarbamazine-albendazole treatment the average mf loss was approximately 83% (ranging from 54% to 100% in the different studies) and worm-productivity loss was 100% (in all studies). For ivermectin-albendazole treatment, average mf loss was 100% (ranging from 98% to 100%) and worm productivity loss was 96% (ranging from 83% to 100%). The effects were dose-dependent. Sensitivity analysis showed that the estimates did not dep...Continue Reading

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Citations

Nov 5, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F BruyèreA Sotto
Jan 15, 2011·Journal of Tropical Medicine·Sumadhya Deepika FernandoSenaka Rajapakse
Feb 16, 2008·Parasites & Vectors·Subramanian SwaminathanDas K Pradeep
Sep 3, 2011·PLoS Neglected Tropical Diseases·Oriol MitjàQuique Bassat
Mar 24, 2011·Future Medicinal Chemistry·Prashant Kumar SinghShailja Misra-Bhattacharya
Jul 23, 2009·Expert Review of Anti-infective Therapy·Henk L Smits
Oct 1, 2007·Expert Opinion on Drug Discovery·Simon TownsonSolomon Nwaka
Mar 20, 2012·Trends in Parasitology·María-Gloria BasáñezThomas S Churcher
Sep 8, 2011·Infectious Disease Clinics of North America·Nisha Jain Garg
May 13, 2008·The Lancet Infectious Diseases·María-Gloria BasáñezMichel Boussinesq
May 1, 2012·PLoS Neglected Tropical Diseases·María-Gloria BasáñezThomas S Churcher

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