Model based conjectures on mammalian clock controversies

Journal of Theoretical Biology
Daniel B Forger, Charles S Peskin

Abstract

We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100:14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBalpha suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the evening and morning oscillator model.

References

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Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daniel B Forger, Charles S Peskin

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Citations

Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Monica Gallego, David M Virshup
Jan 26, 2011·IET Systems Biology·H P MirskyF J Doyle
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·D M VirshupE Vielhaber Harnish
Jan 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel B Forger, Charles S Peskin
May 20, 2008·Biophysical Journal·Stephanie R TaylorLinda R Petzold
Dec 3, 2005·Computational Biology and Chemistry·James M McCollumNagiza F Samatova
Jan 20, 2009·Journal of Biological Rhythms·J M FustinH Dardente
Apr 19, 2007·Journal of Biological Rhythms·Rudiyanto Gunawan, Francis J Doyle
Oct 18, 2018·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ameneh Asgari-Targhi, Elizabeth B Klerman
May 11, 2006·The Journal of Biological Chemistry·Eunyee KwakKyong-Tai Kim
Oct 15, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sachin S TalathiWilliam L Ditto
May 4, 2017·BMC Systems Biology·Olga A PodkolodnayaNikolay L Podkolodnyy
May 13, 2017·Frontiers in Neurology·Rajesh Narasimamurthy, David M Virshup

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