Model-based crosstalk compensation for simultaneous Tc99m∕I123 dual-isotope brain SPECT imaging

Medical Physics
Yong DuEric C Frey

Abstract

In this work, we developed a model-based method to estimate and compensate for the crosstalk contamination in simultaneous I123 and Tc99m dual isotope brain single photo emission computed tomography imaging. The model-based crosstalk compensation (MBCC) includes detailed modeling of photon interactions inside both the object and the detector system. In the method, scatter in the object is modeled using the effective source scatter estimation technique, including contributions from all the photon emissions. The effects of the collimator-detector response, including the penetration and scatter components due to high-energy I123 photons, are modeled using pre-calculated tables of Monte Carlo simulated point-source response functions obtained from sources in air at various distances from the face of the collimator. The model-based crosstalk estimation method was combined with iterative reconstruction based compensation to reduce contamination due to crosstalk. The MBCC method was evaluated using Monte Carlo simulated and physical phantom experimentally acquired simultaneous dual-isotope data. Results showed that, for both experimental and simulation studies, the model-based method provided crosstalk estimates that were in good agre...Continue Reading

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Citations

Feb 6, 2010·Physics in Medicine and Biology·Marlies C Goorden, Freek J Beekman
Jun 28, 2011·Physics in Medicine and Biology·Brian F HuttonFreek J Beekman
Sep 23, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nicolette A LouissaintCraig W Hendrix
Jan 27, 2012·The Journal of Infectious Diseases·Nicolette A LouissaintCraig W Hendrix
Dec 8, 2017·Annals of Nuclear Medicine·Krystyna M JonesMehrbod S Javadi
Jan 4, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yoshihiro YamadaIchiro Matsunari

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