Model-based mapping of fat unsaturation and chain length by chemical shift imaging--phantom validation and in vivo feasibility

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Johan BerglundJoel Kullberg

Abstract

Knowledge about the triglyceride (fat) (1)H spectrum enables quantitative determination of several triglyceride characteristics. This work describes a model-based chemical shift imaging method that separates water and fat signal and provides maps of three triglyceride quantities: fatty acid carbon chain length, unsaturation degree, and polyunsaturation degree. The method was validated by imaging a phantom containing 10 different oils using 1.5 and 3.0 T clinical scanners, with gas-liquid chromatography as reference. Repeated acquisitions demonstrated high reproducibility of the method. Statistical tests of correlation and linear regression were performed to examine the accuracy of the method. Significant correlation was found at both field strengths for all three quantities, and high correlation (r(2) > 0.95) was found for measuring unsaturation degree and polyunsaturation degree. Feasibility of the method for in vivo imaging of the thigh was demonstrated at both field strengths. The estimates of unsaturation degree and polyunsaturation degree in subcutaneous adipose tissue were in agreement with literature values, while chain length appeared over estimated. The method has potential use in large-scale cross-sectional and longit...Continue Reading

References

Feb 1, 1991·The American Journal of Clinical Nutrition·L C HudginsE A Emken
Aug 1, 1989·The American Journal of Clinical Nutrition·G T MalcomJ P Strong
Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonB R Rosen
Dec 1, 1985·The American Journal of Clinical Nutrition·C J FieldM T Clandinin
Feb 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F SchickO Lutz
May 18, 1999·The American Journal of Physiology·L S SzczepaniakD T Stein
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E LunatiF Osculati
Jun 13, 2002·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·B QuerleuxJ Bittoun
Nov 28, 2002·JAMA : the Journal of the American Medical Association·Frank B Hu, Walter C Willett
Jul 20, 2005·Journal of Magnetic Resonance Imaging : JMRI·David K W YeungPing C Leung
Aug 11, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Angel R PinedaNorbert J Pelc
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chia-Ying LiuScott B Reeder
Dec 7, 2007·Chemistry and Physics of Lipids·David K W YeungPing C Leung
Feb 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D HernandoZ-P Liang
May 30, 2008·Journal of Lipid Research·Jimin RenCraig R Malloy
Sep 9, 2008·Journal of Magnetic Resonance Imaging : JMRI·Jingfei Ma
Oct 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Huanzhou YuScott B Reeder
Nov 27, 2008·Progress in Lipid Research·Ulf RisérusFrank B Hu
Jun 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Gavin HamiltonClaude B Sirlin
Feb 4, 2010·Diabetologia·D IggmanU Risérus
Dec 17, 2010·Magnetic Resonance Imaging·Mark BydderClaude B Sirlin
Jan 8, 2011·Radiology·Takeshi YokooClaude B Sirlin
May 4, 2011·NMR in Biomedicine·E James DelikatnyHarish Poptani
Jun 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Huanzhou YuScott B Reeder
Jun 30, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D HernandoS B Reeder
Jul 23, 2011·Journal of Magnetic Resonance Imaging : JMRI·Gavin HamiltonHouchun H Hu
Aug 13, 2011·NMR in Biomedicine·Gavin HamiltonMichael S Middleton
Aug 27, 2011·Magnetic Resonance Imaging·Mark BydderGavin Hamilton

❮ Previous
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Citations

Jun 5, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Jürgen MachannFranz Wolfgang Hirsch
Aug 16, 2014·NMR in Biomedicine·Benjamin LeporqBernard E Van Beers
Oct 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yunjung LeeHyeonjin Kim
Jan 22, 2014·Journal of Magnetic Resonance Imaging : JMRI·Holger Eggers, Peter Börnert
Apr 19, 2013·Journal of Magnetic Resonance Imaging : JMRI·Aliya GiffordE Brian Welch
Dec 12, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pernilla PetersonSven Månsson
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·William T TriplettGlenn A Walter
Oct 15, 2013·NMR in Biomedicine·H H Hu, H E Kan
Feb 16, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pernilla Peterson, Sven Månsson
Oct 29, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Manuel SchneiderMustafa R Bashir
May 8, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lena TrinhSven Månsson
Aug 30, 2016·Journal of Magnetic Resonance Imaging : JMRI·Gavin HamiltonClaude B Sirlin
Jun 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Houchun Harry HuClaude Sirlin
Aug 28, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pernilla PetersonSven Månsson
Nov 4, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benjamin LeporqBernard E Van Beers
Oct 15, 2013·Journal of Magnetic Resonance Imaging : JMRI·Pippa Storey, Arnaldo A Arbini
Feb 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mehran BaboliSungheon Gene Kim
Apr 3, 2014·Topics in Magnetic Resonance Imaging : TMRI·Takeshi Yokoo, Jeffrey D Browning
Nov 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sophia KronthalerDimitrios C Karampinos

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