Model-based predictions of BRCA1/2 mutation status in breast carcinoma patients treated at an academic medical center

Cancer
Kristen M ShannonMichael V Seiden

Abstract

Women with an existing breast carcinoma diagnosis who are found to carry a BRCA1/2 mutation have a substantial risk of developing both a contralateral breast carcinoma and ovarian carcinoma. In a newly diagnosed breast carcinoma patient, this genetic information may influence the management of her disease. To assess the volume of patients who may need genetic services at the time of diagnosis, the authors determined the proportion of women with newly diagnosed breast carcinoma at the study institution who would be eligible for genetic testing. Fifty consecutive women with new breast carcinoma who were attending a multidisciplinary clinic were interviewed. Detailed, three-generation pedigrees were collected for each patient by a genetic counselor. Three commonly used probability models were used to calculate each woman's predicted risk of harboring a germline BRCA1/2 mutation. Eleven of 50 patients (22% [95% confidence interval, 12-36%]) were calculated to have a > or = 10% probability of carrying a BRCA1/2 mutation by at least one mathematic model and should have been offered genetic counseling that included the discussion of genetic testing. There were considerable discrepancies between probability calculations among the three...Continue Reading

References

Sep 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P P RosenD W Kinne
Oct 1, 1995·British Journal of Cancer·D Ford, D F Easton
Jul 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P BroëtB Asselain
Apr 10, 1995·American Journal of Medical Genetics·M J SellerG S Tint
Jan 18, 1996·The New England Journal of Medicine·A A LangstonE A Ostrander
Jan 18, 1996·The New England Journal of Medicine·M G FitzGeraldD A Haber
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Jun 1, 1996·Cancer·E B ClausN J Risch
Feb 5, 1997·Journal of the National Cancer Institute·D A BerryE Winer
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
May 15, 1997·The New England Journal of Medicine·F J CouchB L Weber
May 15, 1997·The New England Journal of Medicine·M KrainerD A Haber
Mar 7, 1998·American Journal of Human Genetics·G ParmigianiO Aguilar
Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Apr 17, 1998·JAMA : the Journal of the American Medical Association·B NewmanM C King
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T S FrankA Thomas
Jan 14, 1999·The New England Journal of Medicine·L C HartmannR B Jenkins

❮ Previous
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Citations

Dec 2, 2004·Nature Reviews. Cancer·Jean-Pierre Issa
Apr 30, 2010·Journal of the National Cancer Institute·Eitan AmirD Gareth Evans
Oct 26, 2006·The American Journal of Surgical Pathology·Gelareh FarshidUNKNOWN Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab)
Sep 16, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Cecelia A BellcrossLorraine T Meisner
Sep 25, 2007·Breast Cancer Research : BCR·D Gareth R Evans, Anthony Howell
Feb 10, 2009·Breast Cancer Research : BCR·Encarna B Gómez GarcíaMaaike P G Vreeswijk
Sep 19, 2009·Annals of Surgical Oncology·P TellerS G A Gabram
Mar 25, 2011·Future Medicinal Chemistry·Sanju NarayananChristopher R McCurdy
Oct 18, 2002·Lancet·Richard D KennedyD Paul Harkin
Feb 13, 2010·The Journal of Obstetrics and Gynaecology Research·Dai KomataKenichi Tanaka
Jul 19, 2015·Journal of the American College of Radiology : JACR·Ankur M VaidyaSusann E Schetter
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Encarna B Gómez-GarcíaArthur van den Wijngaard
Apr 17, 2017·Radiologic Clinics of North America·Lora D Barke, Mary E Freivogel
Aug 7, 2008·Journal of Clinical Pathology·D S P TanJ S Reis-Filho

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