PMID: 8593079Feb 1, 1996Paper

Model-based QSAR for ionizable compounds: toxicity of phenols against Tetrahymena pyriformis

Archives of Environmental Contamination and Toxicology
K PirselováT Wayne Schultz

Abstract

The previously described pseudo-equilibrium model for kinetics of distribution of extraneous chemicals in biological systems has been used for the development of the QSAR equation expressing toxicity of phenols against Tetrahymena pyriformis as a non-linear function of their hydrophobicity and acidity. The model assumes binding of all the tested compounds to a single class of the receptors (i.e., it does not discriminate between possible narcotic and respiratory uncoupling modes of action of phenols) with the association constant related to the electronic structure of the molecules rather than to their hydrophobicity. Non-linear regression analysis revealed satisfying agreement between the model and published biological data measured after a single dose.

References

Jan 1, 1977·Journal of Medicinal Chemistry·R A Scherrer, S M Howard
Jul 1, 1990·Environmental Health Perspectives·H Terada
Jul 1, 1990·Environmental Health Perspectives·G D Veith, S J Broderius
Aug 1, 1989·Bulletin of Environmental Contamination and Toxicology·T W SchultzL L Baker
Jun 1, 1987·Bulletin of Environmental Contamination and Toxicology·T W Schultz
Jul 1, 1987·Toxicology Letters·T W Schultz, M Cajina-Quezada
Oct 1, 1987·Ecotoxicology and Environmental Safety·T W Schultz
Apr 1, 1987·Environmental Health Perspectives·J M McKimG J Niemi
Apr 1, 1985·Toxicology Letters·T W Schultz, G W Riggin
Jul 1, 1980·Physiological Reviews·S G McLaughlin, J P Dilger
Dec 30, 1981·Biochimica Et Biophysica Acta·H Terada
Dec 1, 1982·Ecotoxicology and Environmental Safety·J Saarikoski, M Viluksela
Aug 1, 1980·Journal of Pharmaceutical Sciences·S H Yalkowsky, S C Valvani
Apr 1, 1994·Archives of Environmental Contamination and Toxicology·S E Bryant, T W Schultz

❮ Previous
Next ❯

Citations

Apr 1, 1996·Chemosphere·M T Cronin, T W Schultz
Mar 10, 1999·Chemosphere·M P SauvantE Piccinni
Jun 20, 2002·Journal of Molecular Graphics & Modelling·Stefan Balaz, Viera Lukacova
Jun 25, 1999·Ecotoxicology and Environmental Safety·F BriensS Rault
Oct 1, 2019·Environmental Toxicology and Chemistry·Beate I EscherThomas F Parkerton
Jan 1, 2008·Toxicology Mechanisms and Methods·Todd M MartinDouglas M Young
Mar 7, 2009·Chemical Reviews·Stefan Balaz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.