Model-based versus specific dosimetry in diagnostic context: comparison of three dosimetric approaches

Medical Physics
S MarcatiliManuel Bardiès

Abstract

The dosimetric assessment of novel radiotracers represents a legal requirement in most countries. While the techniques for the computation of internal absorbed dose in a therapeutic context have made huge progresses in recent years, in a diagnostic scenario the absorbed dose is usually extracted from model-based lookup tables, most often derived from International Commission on Radiological Protection (ICRP) or Medical Internal Radiation Dose (MIRD) Committee models. The level of approximation introduced by these models may impact the resulting dosimetry. The aim of this work is to establish whether a more refined approach to dosimetry can be implemented in nuclear medicine diagnostics, by analyzing a specific case. The authors calculated absorbed doses to various organs in six healthy volunteers administered with flutemetamol ((18)F) injection. Each patient underwent from 8 to 10 whole body 3D PET/CT scans. This dataset was analyzed using a Monte Carlo (MC) application developed in-house using the toolkit gate that is capable to take into account patient-specific anatomy and radiotracer distribution at the voxel level. They compared the absorbed doses obtained with GATE to those calculated with two commercially available softw...Continue Reading

References

Apr 1, 1997·IEEE Transactions on Medical Imaging·M DefriseD F Newport
Oct 7, 2003·Radiation Protection Dosimetry·M ZanklD Regulla
Jan 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Antigoni DivoliManuel Bardiès
Mar 5, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wesley E BolchStephen R Thomas
Aug 29, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susan E BuckleyGlenn D Flux
Sep 18, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Glenn D FluxClive L Harmer
Oct 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Robert F HobbsGeorge Sgouros
Jun 18, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yuni K DewarajaAnca M Avram
Sep 18, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Arnaud DieudonnéIsabelle Gardin
Nov 7, 2012·Medical Physics·Ernesto AmatoSergio Baldari
Dec 20, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Arnaud DieudonnéIsabelle Gardin
Mar 22, 2013·Physics in Medicine and Biology·S MarcatiliE Spezi
Dec 4, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim M IllidgeFranck Morschhauser
Jun 12, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Lidia StrigariGlenn Flux
Dec 3, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·E GrassiM Iori

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Citations

Apr 26, 2018·Cancer Biotherapy & Radiopharmaceuticals·Abigail E BesemerBryan P Bednarz
Aug 4, 2020·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Maaike DotingaLioe-Fee de Geus-Oei
Apr 18, 2018·Journal of Anatomy·Hongkai WangChangjian Liu
Feb 10, 2017·Physics in Medicine and Biology·Daphnée VilloingManuel Bardiès
Oct 6, 2017·Radiation Protection Dosimetry·Mahmoud BagheriMohammad Ali Jelodari
Jan 15, 2021·Biomedical Physics & Engineering Express·Daphnée VilloingChoonsik Lee
Dec 16, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Min Sun LeeJae Sung Lee

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