Model-based whole-brain effective connectivity to study distributed cognition in health and disease

Network Neuroscience
M. GilsonAndrea Insabato

Abstract

Neuroimaging techniques are now widely used to study human cognition. The functional associations between brain areas have become a standard proxy to describe how cognitive processes are distributed across the brain network. Among the many analysis tools available, dynamic models of brain activity have been developed to overcome the limitations of original connectivity measures such as functional connectivity. This goes in line with the many efforts devoted to the assessment of directional interactions between brain areas from the observed neuroimaging activity. This opinion article provides an overview of our model-based whole-brain effective connectivity to analyze fMRI data, while discussing the pros and cons of our approach with respect to other established approaches. Our framework relies on the multivariate Ornstein-Uhlenbeck (MOU) process and is thus referred to as MOU-EC. Once tuned, the model provides a directed connectivity estimate that reflects the dynamical state of BOLD activity, which can be used to explore cognition. We illustrate this approach using two applications on task-evoked fMRI data. First, as a connectivity measure, MOU-EC can be used to extract biomarkers for task-specific brain coordination, understo...Continue Reading

References

May 1, 1989·Journal of Neurophysiology·A M AertsenG Palm
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G TononiG M Edelman
Mar 28, 2003·Journal of Neurophysiology·Giovanni d'AvossaMaurizio Corbetta
Sep 2, 2003·NeuroImage·K J FristonW Penny
Oct 7, 2004·Current Opinion in Neurobiology·Klaas E StephanKarl J Friston
Oct 5, 2005·PLoS Computational Biology·Olaf SpornsRolf Kötter
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·M E J Newman
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christopher J HoneyOlaf Sporns
Jul 11, 2007·Journal of the History of the Neurosciences·Jeremy D Schmahmann, Deepak N Pandya
Aug 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Damien A FairBradley L Schlaggar
Apr 29, 2008·Current Biology : CB·Jozien B M Goense, Nikos K Logothetis
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ernesto Estrada, Naomichi Hatano
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Jul 9, 2008·Current Opinion in Neurology·Michael Greicius
Aug 5, 2008·Trends in Neurosciences·Andreas BartelsKonstantinos Moutoussis
Dec 26, 2008·PLoS Biology·Olivier DavidAntoine Depaulis
Jun 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·L BarnettS Bullock
May 18, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn P van den Heuvel, Hilleke E Hulshoff Pol
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Randy L Buckner
Aug 10, 2010·NeuroImage·Thomas NaselarisJack L Gallant
Aug 31, 2010·NeuroImage·Jaroslav HlinkaMaurizio Corbetta
Sep 8, 2010·NeuroImage·Stephen M SmithMark W Woolrich
Dec 21, 2010·Nature Reviews. Neuroscience·Gustavo DecoAnthony R McIntosh
Dec 1, 1998·Trends in Cognitive Sciences·G TononiO Sporns
Apr 12, 2011·NeuroImage·Pedro A Valdes-SosaKarl Friston
Apr 23, 2011·NeuroImage·Joana CabralGustavo Deco
Jul 7, 2011·PLoS Computational Biology·Kay H BrodersenKlaas E Stephan
Jul 8, 2011·Frontiers in Neuroscience·Gorka Zamora-LópezJürgen Kurths
Jul 20, 2011·Human Brain Mapping·R Cameron CraddockHelen S Mayberg
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert BeckerPetra Ritter
Sep 29, 2011·Annual Review of Psychology·Jesse Rissman, Anthony D Wagner
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Biyu J He
Jan 10, 2012·NeuroImage·James B Rowe, Hartwig R Siebner

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Citations

Apr 16, 2020·Frontiers in Neuroscience·Tahereh S ZarghamiFariba Bahrami
Jul 15, 2020·Journal of Neural Engineering·Thomas A W BoltonDimitri Van De Ville
Aug 3, 2021·Frontiers in Genetics·Di LiuZongcheng Li

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Methods Mentioned

BETA
PCA

Software Mentioned

Python
learn
DCM
NetDynFlow
AGAUR
MOU
EC
scikit
pyMOU

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