PMID: 9058222Feb 1, 1997

Model-driven closed-loop feedback infusion of atracurium and vecuronium during hypothermic cardiopulmonary bypass

Journal of Cardiothoracic and Vascular Anesthesia
M KansanahoK T Olkkola


This study was designed to investigate the performance of a computer-controlled infusion of atracurium and vecuronium during cardiac surgery requiring hypothermic cardiopulmonary bypass. Prospective, randomized study. A single university hospital. Twenty patients scheduled for cardiac surgery. After induction of anesthesia with fentanyl and diazepam, 10 patients were randomly allocated to receive a bolus of atracurium and 10 patients a bolus dose of vecuronium to facilitate endotracheal intubation. The initial bolus was followed by a computer-controlled closed-loop feedback infusion of atracurium or vecuronium until the patients were transferred to the postoperative intensive care unit. The desired level of neuromuscular blockade, as measured by EMG, was set to 90%. Anesthesia was maintained with a mixture of oxygen and air and either enflurane or halothane. The groups were similar with respect to patient characteristics. Except during hypothermic CPB, the controller kept the neuromuscular blockade near the set point in both groups. During hypothermic CPB the maximal oscillation of muscle relaxation was within 10% from the set point. When CPB was initiated, the mean rates of infusion of the muscle relaxants increased from the p...Continue Reading


Jul 1, 1989·Clinical Pharmacokinetics·W A BuylaertM G Bogaert
Oct 1, 1984·Anesthesiology·R D MillerY J Sohn


Jan 2, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D WithingtonF Varin
Oct 5, 2006·Current Opinion in Anaesthesiology·M StruysE Mortier
Jul 8, 2008·Annals of Cardiac Anaesthesia·Thomas M HemmerlingDavid Bracco
Jul 25, 2019·Brain and Behavior·Anna SójkaMariusz Pryliński
Mar 20, 2015·Anesthesia and Analgesia·Aaron E BarryMartin J London
May 15, 2018·F1000Research·Mohamed Mahmoud, Keira P Mason

Related Concepts

Cardiopulmonary Bypass
Neuromuscular Nondepolarizing Agents
Surface Electromyography
Cardiac Surgery Procedures
Mild Hypothermia, Induced
Intravenous Infusion Procedures
Vecuronium Bromide, Quaternary Ion
Induction of Neuromuscular Blockade

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