Model explaining the relation between distal nephron Li+ reabsorption and urinary Na+ excretion in rats

The American Journal of Physiology
M ShalmiS Christensen

Abstract

Li+ may be reabsorbed via an amiloride-sensitive mechanism in the collecting ducts of rats administered a low-Na+ diet. This was investigated by measuring the increase in fractional urinary excretion of Li+ (FELi) in response to amiloride in conscious rats at two different levels of plasma Li+ concentration and after administration of bendroflumethiazide (BFTZ), angiotensin III (ANG III), and aldosterone (Aldo). The results confirmed that amiloride increased (FELi) in rats on a low-Na+ diet (20 +/- 1 to 35 +/- 1%, means +/- SE), whereas no increase was observed in rats on a normal Na+ diet (37 +/- 1 to 38 +/- 1%). The lithiuretic effect of amiloride was 1) abolished by preadministration of BFTZ (32 +/- 1 to 33 +/- 2%) to Na(+)-deprived rats and 2) increased by ANG III (27 +/- 3 to 33 +/- 2%) and Aldo (25 +/- 2 to 37 +/- 2%) in Na(+)-replete rats. Amiloride-induced changes in FELi were independent of plasma Li+ concentration but inversely related to the fractional excretion of Na+ and the amiloride-sensitive excretion of K+. These results are compatible with the hypothesis that a low tubular Na+ concentration reduces end-tubular Na+ reabsorption and results in hyperpolarization of the apical membrane, thus favoring Li+ uptake in...Continue Reading

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Citations

Dec 8, 2005·American Journal of Physiology. Renal Physiology·Jakob NielsenSøren Nielsen
Jan 25, 2008·American Journal of Physiology. Renal Physiology·Jennifer J BedfordRobert J Walker
Jul 28, 2018·Frontiers in Physiology·Stine Julie TingskovRikke Nørregaard
Nov 9, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mads Kjolby, Peter Bie
Sep 1, 2000·American Journal of Physiology. Renal Physiology·T H KwonS Nielsen
Jan 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Klaus Thomsen, David G Shirley
Jul 9, 2002·Acta Physiologica Scandinavica·T E N JonassenS Christensen

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