PMID: 6987654Jan 1, 1980Paper

Model for regulation of the histidine operon of Salmonella

Proceedings of the National Academy of Sciences of the United States of America
H M JohnstonJ R Roth

Abstract

A model is proposed that accounts for regulation of the histidine operon by a mechanism involving alternative configuration of mRNA secondary structure (the alternative stem model). New evidence for the model includes sequence data on three regulatory mutations. The first (hisO1242) is a mutation that deletes sequences needed to form the attenuator mRNA stem and causes constitutive operon expression. The second mutation (hisO9654) is a His- ochre (UAA) mutation in the leader peptide gene; the existence of this mutation constitutes evidence that the leader peptide gene is translated. The third mutation (hisO9663) is remarkable. It neither generates a nonsense codon nor affects a translated sequence; yet, it is suppressible by amber suppressors. We believe this mutation causes a His- phenotype by interfering with mRNA secondary structure. The suppressibility of the mutation is probably due to disruption of the attenuator stem by ribosomes that read through the terminator codon of the leader peptide gene. This explanation is supported by the observation of derepression of a wild-type control region in the presence of an amber suppressor. Evidence is presented that hisT mutants (which lack pseudouridine in the anticodon arm of hist...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D L OxenderC Yanofsky
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J F Gardner
Jun 1, 1977·Nucleic Acids Research·L Bossi, R Cortese
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F Lee, C Yanofsky
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G ZurawskiC Yanofsky
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P P Di NoceraC B Bruni
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W M Barnes
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A M Wu, T Platt
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G V StaufferC Yanofsky
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R M GemmillJ M Calvo
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S W Artz, J R Broach
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J F ScottS W Artz
Jul 15, 1974·Journal of Molecular Biology·P N BorerO C Uhlenbeck

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Citations

Jan 1, 1980·Molecular & General Genetics : MGG·L G CassG Wilcox
Jan 1, 1983·Molecular & General Genetics : MGG·L Bossi
Jan 1, 1984·Molecular & General Genetics : MGG·T G Hagervall, G R Björk
Jan 1, 1985·Molecular & General Genetics : MGG·D M Kinney, J W Foster
Jan 1, 1982·Molecular & General Genetics : MGG·J Parker
Apr 1, 1989·Molecular & General Genetics : MGG·J Casadesus, J R Roth
Jan 1, 1983·Molecular & General Genetics : MGG·P PutnokyA Kondorosi
Jun 1, 1990·FEMS Microbiology Letters·I Gibert, J Casadesús
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S Horinouchi, B Weisblum
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y GluzmanR J Frisque
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D I FriedmanS L Adhya
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R FrunzioF Blasi
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·I FinancsekM Muramatsu
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P FridenM Freundlich
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C F Higgins, G F Ames
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B N AmesM F Christman
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C L TurnboughJ P Donahue
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M Navre, H K Schachman
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K E Rudd, R Menzel
Dec 21, 1981·Nucleic Acids Research·C YanofskyA M Wu
Oct 15, 1991·European Journal of Biochemistry·R M MansL Bosch
Oct 23, 2012·Science·Joakim NäsvallDan I Andersson
Jun 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Charles L Turnbough, Robert L Switzer
Jun 15, 2006·Annual Review of Microbiology·Diana M Downs
Jun 6, 2014·PLoS Genetics·Fabienne F V ChevanceKelly T Hughes
Dec 4, 2012·Biochimica Et Biophysica Acta·Yuri A NedialkovZachary F Burton
Apr 27, 2013·Microbial Biotechnology·Robert K Kulis-HornJörn Kalinowski
Feb 5, 1981·Journal of Molecular Biology·F G Chumley, J R Roth
Jul 15, 1981·Journal of Molecular Biology·S R Wessler, J M Calvo

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