Model for the dielectric properties of human lung tissue against frequency and air content

Medical & Biological Engineering & Computing
P NoppB H Brown

Abstract

Electrical impedance tomographic spectroscopy measurements of the lungs are taken from nine normal subjects, in the frequency range 9.6 kHz-1.2 MHz. The results show that resistivity rho'FRC relative to functional residual capacity increases almost linearly with inspiration volume V, with the slope of the curve increasing with frequency f. Resistivity rho'9.6 kHz relative to 9.6 kHz decreases with f. rho'9.6 kHz increases with V, at any given frequency. Curves for rho'9.6 kHz show a roughly linear trend with log10(f). Based on a discussion of the measurement results, a mathematical lung tissue model is designed that involves extra-capillary blood vessels and alveoli, the walls of which consist of blood-filled capillaries, epithelial cells and intercellular liquid. Using this model, the increase in rho'FRC with V is explained by the thinning of alveolar walls with increasing air content. The almost linear shape of curves for rho'9.6 kHz is attributed to four partly overlapping main dispersions caused by extra-capillary blood vessels, epithelial cells, blood and the capillary network.

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Citations

Sep 14, 2002·Medical & Biological Engineering & Computing·B H BrownM J Jackson
Nov 28, 2002·Medical & Biological Engineering & Computing·B H BrownM J Jackson
Apr 2, 2008·Critical Care Medicine·Eduardo L V CostaMarcelo B P Amato
Dec 25, 2003·American Journal of Respiratory and Critical Care Medicine·Josué A VictorinoMarcelo B P Amato
Nov 13, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Mouloud A DenaïGary H Mills
Jan 18, 2005·Respiratory Physiology & Neurobiology·T YamashiroS Sasaguri
Jun 15, 2010·IEEE Transactions on Bio-medical Engineering·Ville-Pekka SeppäJari Hyttinen
Oct 18, 2014·European Journal of Applied Physiology·João Batista BorgesStéphanie Montmerle-Borgdorff
Mar 31, 2005·Physiological Measurement·Michael MayerHermann Scharfetter
Feb 4, 2009·Current Opinion in Critical Care·Eduardo L V CostaMarcelo B P Amato
Nov 4, 2011·Physiological Measurement·Satoru NebuyaBrian H Brown
Dec 29, 2011·Current Opinion in Critical Care·Stefan Lundin, Ola Stenqvist
Jul 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R J M NavestC A T van den Berg
May 23, 2014·Physiological Measurement·Bartłomiej Grychtol, Andy Adler
May 27, 2015·Physiological Measurement·Christian J RothWolfgang A Wall
Oct 5, 2013·Journal of Applied Physiology·Ville-Pekka SeppäL Pekka Malmberg
Dec 10, 2016·Journal of Applied Physiology·Christian J RothWolfgang A Wall
Dec 11, 1999·Physiological Measurement·R H SmallwoodP Nopp
Mar 10, 2001·Physiological Measurement·A J WilsonB H Brown
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Oct 1, 2011·Journal of Applied Physiology·João Batista BorgesMarcelo Amato
Jan 28, 2020·Annual Reviews in Control·Thiago de Castro MartinsMarcos de Sales Guerra Tsuzuki

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