Model-free age-of-onset methods applied to the linkage of bipolar disorder

Genetic Epidemiology
X ZhuRobert C Elston

Abstract

We performed Haseman-Elston regression on a set of bipolar pedigrees using each of three dependent variables: a binary trait indicating disease concordance or discordance, a binary trait adjusted for age-of-onset, and the residuals from a survival analysis. The latter two methods, which both adjust for age-of-onset, gave smaller p-values when previous analyses suggested linkage between disease and marker, but not when previous analyses were not suggestive of linkage.

References

Jan 1, 1988·Basic Life Sciences·R C Elston
Mar 1, 1972·Behavior Genetics·J K Haseman, R C Elston

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