Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4

American Journal of Human Genetics
K A GoddardJane M Olson

Abstract

As with many complex genetic diseases, genome scans for prostate cancer have given conflicting results, often failing to provide replication of previous findings. One factor contributing to the lack of consistency across studies is locus heterogeneity, which can weaken or even eliminate evidence for linkage that is present only in a subset of families. Currently, most analyses either fail to account for locus heterogeneity or attempt to account for it only by partitioning data sets into smaller and smaller portions. In the present study, we model locus heterogeneity among affected sib pairs with prostate cancer by including covariates in the linkage analysis that serve as surrogate measures of between-family linkage differences. The model is a modification of the Olson conditional logistic model for affected relative pairs. By including Gleason score, age at onset, male-to-male transmission, and/or number of affected first-degree family members as covariates, we detected linkage near three locations that were previously identified by linkage (1q24-25 [HPC1; LOD score 3.25, P=.00012], 1q42.2-43 [PCAP; LOD score 2.84, P=.0030], and 4q [LOD score 2.80, P=.00038]), near the androgen-receptor locus on Xq12-13 (AR; LOD score 3.06, P=...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B S CarterP C Walsh
Dec 1, 1995·The Journal of Urology·D W KeetchW J Catalona
Aug 1, 1995·Nature Medicine·K R MonroeB E Henderson
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·D M ParkinJ Ferlay
Jan 15, 1997·Journal of the National Cancer Institute·S A InglesG A Coetzee
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·E GiovannucciP W Kantoff
Jul 2, 1997·Journal of the National Cancer Institute·K A CooneyK Lange
Dec 31, 1997·Journal of the National Cancer Institute·C L HsiehA S Whittemore
Jun 19, 1998·American Journal of Human Genetics·P BerthonO Cussenot
May 23, 1998·American Journal of Human Genetics·A S Whittemore, I P Tu
Jul 22, 1998·Genetic Epidemiology·M I McCarthyE S Lander
Aug 27, 1998·American Journal of Human Genetics·K W BromanJ L Weber
Mar 3, 1999·American Journal of Human Genetics·M GibbsE A Ostrander
Mar 3, 1999·American Journal of Human Genetics·C M Greenwood, S B Bull
Mar 26, 1999·American Journal of Human Genetics·M GibbsE A Ostrander
Dec 1, 1999·American Journal of Human Genetics·J M Olson
Mar 11, 2000·American Journal of Human Genetics·B K SuarezW J Catalona
Mar 21, 2000·Genetic Epidemiology·E L GoodeG P Jarvik
May 23, 2000·American Journal of Human Genetics·M GibbsL Hood
May 23, 2000·American Journal of Human Genetics·R BerryD J Schaid
May 29, 2000·American Journal of Human Genetics·J S WitteW J Catalona
Jun 22, 2000·Genetic Epidemiology·R C ElstonJ M Olson
Nov 9, 2000·American Journal of Human Genetics·E A Ostrander, J L Stanford

❮ Previous
Next ❯

Citations

Jul 28, 2011·JAMA : the Journal of the American Medical Association·Mohammed OrloffCharis Eng
Sep 25, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Dimitrios AvramopoulosSusan S Bassett
Aug 26, 2006·Human Genetics·Daniel J SchaidUNKNOWN Investigators of the International Consortium for Prostate Cancer Genetics
Jul 2, 2009·Human Genetics·Cathryn Hufford BockBenjamin A Rybicki
Jun 21, 2006·Behavior Genetics·Catherine M SteinSudha K Iyengar
Sep 13, 2007·Cancer Metastasis Reviews·Yong Q ChenIsabelle M Berquin
Jul 20, 2002·Current Psychiatry Reports·Anne S BassettLinda Brzustowicz
Oct 16, 2002·Cancer Genetics and Cytogenetics·Gregory A HawkinsJianfeng Xu
May 1, 2012·Asian Journal of Andrology·William B Isaacs
Oct 3, 2008·European Journal of Human Genetics : EJHG·Liesel M FitzGeraldJoanne L Dickinson
Dec 4, 2013·Nature Reviews. Urology·Rosalind EelesZsofia Kote-Jarai
May 1, 2013·Prostate Cancer and Prostatic Diseases·M P ZeegersH Ostrer
Mar 10, 2005·European Journal of Human Genetics : EJHG·Ronald E BlantonKatrina Ab Goddard
Dec 7, 2006·European Journal of Human Genetics : EJHG·Jérémie NsengimanaUNKNOWN British Heart Foundation Family Heart Study Research Group
May 4, 2007·Genes and Immunity·B A RybickiUNKNOWN SAGA Study Consortium
Aug 19, 2004·Journal of the National Cancer Institute·Elizabeth M GillandersJeffrey M Trent
Oct 16, 2004·Annual Review of Genomics and Human Genetics·Elaine A OstranderJanet L Stanford
Jul 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joan P BreyerJeffrey R Smith
Dec 8, 2004·Human Heredity·James K BurmesterWilliam J Catalona
Jun 15, 2007·Human Heredity·Daniel J SchaidStephen N Thibodeau
Feb 3, 2006·BMC Genetics·Guy N BrockMary L Marazita
Apr 28, 2005·BMC Medical Genetics·Joseph P BroderickRobert D Brown
Jan 1, 2004·Hereditary Cancer in Clinical Practice·Sashi KommuRosalind Eeles
Dec 24, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·B K PodisiP M Hocking
Mar 28, 2006·Future Oncology·Todd ThornburgJianfeng Xu
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Danielle M FriedrichsenJianfeng Xu
Dec 21, 2004·Human Genomics·Robert C Elston, Courtney Gray-McGuire
Apr 15, 2014·The Urologic Clinics of North America·Brian T Helfand, William J Catalona

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.