Model misspecification and robustness in causal inference: comparing matching with doubly robust estimation

Statistics in Medicine
Ingeborg Waernbaum

Abstract

In this paper, we compare the robustness properties of a matching estimator with a doubly robust estimator. We describe the robustness properties of matching and subclassification estimators by showing how misspecification of the propensity score model can result in the consistent estimation of an average causal effect. The propensity scores are covariate scores, which are a class of functions that removes bias due to all observed covariates. When matching on a parametric model (e.g., a propensity or a prognostic score), the matching estimator is robust to model misspecifications if the misspecified model belongs to the class of covariate scores. The implication is that there are multiple possibilities for the matching estimator in contrast to the doubly robust estimator in which the researcher has two chances to make reliable inference. In simulations, we compare the finite sample properties of the matching estimator with a simple inverse probability weighting estimator and a doubly robust estimator. For the misspecifications in our study, the mean square error of the matching estimator is smaller than the mean square error of both the simple inverse probability weighting estimator and the doubly robust estimators.

References

Feb 12, 1998·Annals of Internal Medicine·D B Rubin
Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Jan 13, 2006·Biometrics·Heejung Bang, James M Robins
Jun 3, 2008·Statistical Science : a Review Journal of the Institute of Mathematical Statistics·Anastasios A Tsiatis, Marie Davidian
Sep 28, 2010·Statistical Science : a Review Journal of the Institute of Mathematical Statistics·Elizabeth A Stuart

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Citations

May 2, 2000·The Journal of the Acoustical Society of America·D Tang, T H Orsi
Jun 1, 2012·BMC Medical Research Methodology·Romain PirracchioSylvie Chevret
Oct 12, 2013·Preventive Veterinary Medicine·Wayne Martin
May 28, 2015·Statistics in Medicine·Roee Gutman, Donald B Rubin
Feb 4, 2016·Journal of the Royal Statistical Society. Series C, Applied Statistics·Maria JosefssonLars Nyberg
Jun 14, 2013·Statistics in Medicine·Arvid Sjölander, Sander Greenland
May 14, 2016·International Journal of Epidemiology·Urban LindgrenAnneli Ivarsson
Nov 30, 2014·Statistical Methods in Medical Research·Michael J Lopez, Roee Gutman
Feb 26, 2015·Statistical Methods in Medical Research·R Gutman, D B Rubin
Aug 14, 2018·Statistics in Medicine·Lauren R Samuels, Robert A Greevy
May 12, 2018·Biometrics·Joseph AntonelliDenis Agniel
Jun 9, 2017·Emerging Themes in Epidemiology·Tomohiro ShinozakiYutaka Matsuyama
Jun 11, 2021·Epidemiologic Reviews·Noah Greifer, Elizabeth A Stuart

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