Model of anaesthetic induction by unilateral intracerebral microinjection of GABAergic agonists

The European Journal of Neuroscience
M DevorAnne Minert

Abstract

General anaesthetic agents induce loss of consciousness coupled with suppression of movement, analgesia and amnesia. Although these diverse functions are mediated by neural structures located in wide-ranging parts of the neuraxis, anaesthesia can be induced rapidly and reversibly by bilateral microinjection of minute quantities of γ-aminobutyric acid (GABA)A -R agonists at a small, focal locus in the mesopontine tegmentum (MPTA). State switching under these circumstances is presumably executed by dedicated neural pathways and does not require widespread distribution of the anaesthetic agent itself, the classical assumption regarding anaesthetic induction. Here it was asked whether these pathways serve each hemisphere independently, or whether there is bilateral redundancy such that the MPTA on each side is capable of anaesthetizing the entire brain. Either of two GABAA -R ligands were microinjected unilaterally into the MPTA in awake rats, the barbiturate modulator pentobarbital and the direct receptor agonist muscimol. Both agents, microinjected on either side, induced clinical anaesthesia, including bilateral atonia, bilateral analgesia and bilateral changes in cortical activity. The latter was monitored using c-fos expressio...Continue Reading

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Citations

Oct 21, 2016·Anesthesia and Analgesia·Inna SukhotinskyMarshall Devor
May 31, 2020·The Journal of Comparative Neurology·Robert P Vertes, Stephanie B Linley
Jul 1, 2020·Neuroscience Letters·Shai-Lee YatzivMarshall Devor
Aug 31, 2021·Experimental Brain Research·Shai-Lee YatzivMarshall Devor

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