Model-Predicted Balance Between Neural Excitation and Inhibition Was Maintained Despite of Age-Related Decline in Sensory Evoked Local Field Potential in Rat Barrel Cortex

Frontiers in Systems Neuroscience
Sungmin KangYing Zheng

Abstract

The balance between neural excitation and inhibition has been shown to be crucial for normal brain function. However, it is unclear whether this balance is maintained through healthy aging. This study investigated the effect of aging on the temporal dynamics of the somatosensory evoked local field potential (LFP) in rats and tested the hypothesis that excitatory and inhibitory post-synaptic activities remain balanced during the aging process. The LFP signal was obtained from the barrel cortex of three different age groups of anesthetized rats (pre-adolescence: 4-6 weeks, young adult: 2-3 months, middle-aged adult: 10-20 months) under whisker pad stimulation. To confirm our previous finding that the initial segment of the evoked LFP was solely associated with excitatory post-synaptic activity, we micro-injected gabazine into the barrel cortex to block inhibition while LFP was collected continuously under the same stimulus condition. As expected, the initial slope of the evoked LFP in the granular layer was unaffected by gabazine injection. We subsequently estimated the excitatory and inhibitory post-synaptic activities through a balanced model of the LFP with delayed inhibition as an explicit constraint, and calculated the ampli...Continue Reading

References

Nov 1, 1976·Experimental Aging Research·J Roberts, P B Goldberg
Jul 4, 2001·Neurophysiologie clinique = Clinical neurophysiology·M OnofrjC Paci
Sep 29, 2001·British Journal of Anaesthesia·S K PalD C White
Jul 25, 2003·British Journal of Anaesthesia·R W D Nickalls, W W Mapleson
Sep 2, 2003·NeuroImage·K J FristonW Penny
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
May 4, 2004·Journal of the American Academy of Audiology·Kelly L TremblayNeeru Rohila
Jun 15, 2004·NeuroImage·Myles JonesJohn Mayhew
Sep 1, 2004·Journal of Neural Transmission·P MissonnierP Giannakopoulos
Jun 7, 2005·Academic Radiology·Aylin TekesDavid M Yousem
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael J Higley, Diego Contreras
Nov 28, 2007·Annual Review of Pathology·Bruce A YanknerPatrick Loerch
Jan 11, 2008·The European Journal of Neuroscience·Annette Sterr, Philip Dean
Jan 12, 2008·Annals of Biomedical Engineering·Axel Schäfer, Karl W Kratky
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hajime SatoYoungnam Kang
May 10, 2008·Nature Reviews. Neuroscience·Paulo S Pinheiro, Christophe Mulle
May 21, 2008·The Journal of Experimental Biology·Donald M CasparyLarry F Hughes
Aug 8, 2009·The European Journal of Neuroscience·Kazuto MasamotoSeong-Gi Kim
Aug 12, 2009·Frontiers in Integrative Neuroscience·Peter J UhlhaasWolf Singer
Sep 12, 2009·Cerebral Cortex·Marianne David-Jürgens, Hubert R Dinse
Jan 26, 2010·NeuroImage·S Coombes
Mar 26, 2010·Nature·Nicholas A BishopBruce A Yankner
Apr 7, 2010·Brain Topography·Ingo BojakRolf Kötter
Jan 31, 2012·Journal of the American Academy of Audiology·Dawn Konrad-MartinDonald F Austin
May 19, 2012·Nature Reviews. Neuroscience·György BuzsákiChristof Koch
Sep 13, 2012·Frontiers in Human Neuroscience·Bernadette C M van WijkAndreas Daffertshofer
Nov 1, 2012·Frontiers in Neuroanatomy·Priscilla Morterá, Suzana Herculano-Houzel
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cyril BoriesYves De Koninck
Mar 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo MostanyCarlos Portera-Cailliau

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Barrel cortex

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