Model studies of leukocyte-endothelium-blood interactions. II. Hemodynamic impact of leukocytes adherent to the wall of post-capillary vessels

Biorheology
G B Chapman, G R Cokelet

Abstract

Computational fluid dynamics (CFD) and large scale model experiments were used to analyze the hemodynamic impact of leukocytes adherent to the wall of post-capillary venules. Using a large scale model and, with the aid of a finite element package, solving the Navier Stokes equations for low Reynolds number flow in a cylinder past an adherent sphere, we have developed a dimensionless correlation which permits the estimation of the pressure drop across an adherent leukocyte in an in vivo vessel. This relationship is: f.Re = exp[2.877+4.630 (d/D)4] where f is the Fanning friction factor, Re is the Reynolds number and d/D is the leukocyte to vessel diameter ratio. The friction factor is proportional to the pressure drop across the leukocyte, and does not significantly increase until d/D is greater than 0.5, and then increases rapidly with increasing d/D. Computations indicate that the length of the disturbed flow region generated by an adherent leukocyte increases with decreasing vessel size. The average wall stress in the disturbed flow region remains constant, and equal to the wall stress in the undisturbed region for d/D less than approximately 0.5. For d/D greater than 0.5, the average wall stress in the disturbed flow region i...Continue Reading

References

Jan 1, 1975·Circulation Research·G W Schmid-SchoenbeinB W Zweifach
Jul 1, 1990·Microvascular Research·K C Warnke, T C Skalak
Feb 1, 1989·Pflügers Archiv : European journal of physiology·T N ThompsonG R Cokelet
Nov 1, 1987·Microvascular Research·S D House, H H Lipowsky

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Citations

Mar 13, 2010·Biomechanics and Modeling in Mechanobiology·W W YanB M Fu
Oct 16, 2012·Biomedical Microdevices·Phillip A CoghillDavid W Schmidtke
Nov 19, 2003·Journal of Biomechanical Engineering·Masako Sugihara-Seki, Geert W Schmid-Schönbein
Mar 10, 2006·Journal of Biomechanical Engineering·Jordan Leyton-MangeCheng Dong
May 20, 2009·Biophysical Journal·John E Pickard, Klaus Ley
Jul 4, 2008·Journal of Theoretical Biology·Vijay PappuProsenjit Bagchi
Jul 19, 2011·Microvascular Research·Balabhaskar PrabhakarpandianMohammad F Kiani

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